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Measurement Properties of the EQ-5D-5L and EQ-5D-3L in Six Commonly Diagnosed Cancers

Author

Listed:
  • Xueyun Zeng

    (Harbin Medical University)

  • Mingjie Sui

    (Harbin Medical University)

  • Bo Liu

    (Harbin Medical University)

  • Hongbin Yang

    (The Third Affiliated Hospital of Harbin Medical University)

  • Rui Liu

    (Harbin Medical University)

  • Rachel Lee-Yin Tan

    (National University of Singapore, Saw Swee Hock School of Public Health)

  • Juan Xu

    (Harbin Medical University)

  • Erwei Zheng

    (The First Affiliated Hospital of Harbin Medical University)

  • Jinjin Yang

    (Harbin Medical University)

  • Chunyu Liu

    (Tianjin Health Development Research Center)

  • Weidong Huang

    (Harbin Medical University)

  • Hongjuan Yu

    (Southern University of Science and Technology Hospital)

  • Nan Luo

    (National University of Singapore, Saw Swee Hock School of Public Health)

Abstract

Background This study aimed to compare the measurement properties of the EQ-5D-3L (3L) and EQ-5D-5L (5L) in cancer patients. Methods A consecutive sample of inpatients with lung, breast, colorectal, liver, gastric, or thyroid cancer were interviewed using the 3L, 5L, and Functional Assessment of Cancer Therapy–General (FACT-G) questionnaires, and a subgroup was invited to complete the 3L and 5L again. Kappa and intraclass correlation coefficient were used to assess test–retest reliability, and Spearman’s correlation between the EQ-5D and FACT-G was evaluated to assess convergent validity. Comparison of subgroups defined using Eastern Cooperative Oncology Group status and cancer stage were performed to assess known-group validity and discriminatory power using the F-statistic and area under the receiver-operating characteristics curve. All analyses were also performed for each subgroup of cancer patients. Results A total of 416 cancer patients completed the baseline questionnaire and 90 patients also completed the follow-up survey after 2 days. Ceiling effects were smaller in 5L (10.1%) than in 3L (17.8%). The test–retest reliability and convergent validity of the 5L were slightly better than those of the 3L. Both the 3L and 5L showed known-group validity; however, the 5L index showed better discriminatory power. Similar trends were found in the six types of cancers. Conclusion In general, 5L appears to have better measurement properties than 3L for measuring the health-related quality of life of cancer patients. While both the 3L and 5L are suitable, 5L should be preferable to 3L for use in cancer outcomes research.

Suggested Citation

  • Xueyun Zeng & Mingjie Sui & Bo Liu & Hongbin Yang & Rui Liu & Rachel Lee-Yin Tan & Juan Xu & Erwei Zheng & Jinjin Yang & Chunyu Liu & Weidong Huang & Hongjuan Yu & Nan Luo, 2021. "Measurement Properties of the EQ-5D-5L and EQ-5D-3L in Six Commonly Diagnosed Cancers," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 14(2), pages 209-222, March.
    • Handle: RePEc:spr:patien:v:14:y:2021:i:2:d:10.1007_s40271-020-00466-z
    DOI: 10.1007/s40271-020-00466-z
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    References listed on IDEAS

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    1. Nick Bansback & Aki Tsuchiya & John Brazier & Aslam Anis, 2012. "Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
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