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Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis

Author

Listed:
  • Biruk Beletew Abate

    (Woldia University)

  • Ayelign Mengesha Kasie

    (Woldia University)

  • Melese Abate Reta

    (Woldia University
    University of Pretoria)

  • Mesfin Wudu Kassaw

    (Woldia University)

Abstract

Objectives This systematic review and meta-analysis aimed to reveal the magnitude of neonatal sepsis and its associated factors in East Africa. Methods Using PRISMA guideline, we reviewed and meta-analyzed studies from Google Scholar, Cochrane library, and PubMed; last search date: October 15, 2019. Heterogeneity across the studies was estimated. The subgroup analysis was done. Publication bias was also assessed. Results A total of 26 studies with 11,239 participants are included. The pooled prevalence of neonatal sepsis in East Africa was 29.765% (95% CI 23.36–35.94). Home delivery (AOR = 2.67; 95% CI 1.15–4.00), maternal history of urinary tract infection (UTI) (AOR = 2.083; 95% CI 0.24–3.93), gestational age/(preterm) (AOR = 1.56; 95% CI 1.04–2.08), prolonged labor (AOR = 3.23; 95% CI 0.04–6.51) and PROM (AOR = 1.95; 95% CI 0.53–3.37) were identified associated factors of neonatal sepsis. Conclusions The prevalence of neonatal sepsis in East Africa remains high. The relevant stockholders should give attention for neonates delivered from women with intranatal fever to prevent neonatal sepsis. Pregnant women should be screened for UTI. Appropriate interventions should be put in place to manage PROM to decrease the chance of ascending microorganisms.

Suggested Citation

  • Biruk Beletew Abate & Ayelign Mengesha Kasie & Melese Abate Reta & Mesfin Wudu Kassaw, 2020. "Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(9), pages 1623-1633, December.
    • Handle: RePEc:spr:ijphth:v:65:y:2020:i:9:d:10.1007_s00038-020-01489-x
    DOI: 10.1007/s00038-020-01489-x
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    References listed on IDEAS

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    1. Grace J Chan & Anne CC Lee & Abdullah H Baqui & Jingwen Tan & Robert E Black, 2013. "Risk of Early-Onset Neonatal Infection with Maternal Infection or Colonization: A Global Systematic Review and Meta-Analysis," PLOS Medicine, Public Library of Science, vol. 10(8), pages 1-20, August.
    2. Shruti Murthy & Myron Anthony Godinho & Vasudeva Guddattu & Leslie Edward Simon Lewis & N Sreekumaran Nair, 2019. "Risk factors of neonatal sepsis in India: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-26, April.
    3. Leontine Alkema & Jin Rou New & Jon Pedersen & Danzhen You & all members of the UN Inter-agency Group for Child Mortality Estimation and its Technical Advisory Group, 2014. "Child Mortality Estimation 2013: An Overview of Updates in Estimation Methods by the United Nations Inter-Agency Group for Child Mortality Estimation," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-13, July.
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