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Incidence and costs of hospitalized adult influenza patients in The Netherlands: a retrospective observational study

Author

Listed:
  • Sierk D. Marbus

    (National Institute for Public Health and the Environment (RIVM))

  • Valentijn A. Schweitzer

    (University Medical Center Utrecht)

  • Geert H. Groeneveld

    (Leiden University Medical Center)

  • Jan J. Oosterheert

    (University Medical Centre Utrecht)

  • Peter M. Schneeberger

    (Regional Laboratory for Medical Microbiology and Infection Prevention)

  • Wim Hoek

    (National Institute for Public Health and the Environment (RIVM))

  • Jaap T. Dissel

    (National Institute for Public Health and the Environment (RIVM)
    Leiden University Medical Center)

  • Arianne B. Gageldonk-Lafeber

    (National Institute for Public Health and the Environment (RIVM))

  • Marie-Josée Mangen

    (National Institute for Public Health and the Environment (RIVM))

Abstract

Objective Influenza virus infections cause a high disease and economic burden during seasonal epidemics. However, there is still a need for reliable disease burden estimates to provide a more detailed picture of the impact of influenza. Therefore, the objectives of this study is to estimate the incidence of hospitalisation for influenza virus infection and associated hospitalisation costs in adult patients in the Netherlands during two consecutive influenza seasons. Methods We conducted a retrospective study in adult patients with a laboratory confirmed influenza virus infection in three Dutch hospitals during respiratory seasons 2014–2015 and 2015–2016. Incidence was calculated as the weekly number of hospitalised influenza patients divided by the total population in the catchment populations of the three hospitals. Arithmetic mean hospitalisation costs per patient were estimated and included costs for emergency department consultation, diagnostics, general ward and/or intensive care unit admission, isolation, antibiotic and/or antiviral treatment. These hospitalisation costs were extrapolated to national level and expressed in 2017 euros. Results The study population consisted of 380 hospitalised adult influenza patients. The seasonal cumulative incidence was 3.5 cases per 10,000 persons in respiratory season 2014–2015, compared to 1.8 cases per 10,000 persons in 2015–2016. The arithmetic mean hospitalisation cost per influenza patient was €6128 (95% CI €4934–€7737) per patient in 2014–2015 and €8280 (95% CI €6254–€10,665) in 2015–2016, potentially reaching total hospitalisation costs of €28 million in 2014–2015 and €20 million in 2015–2016. Conclusions Influenza virus infections lead to 1.8–3.5 hospitalised patients per 10,000 persons, with mean hospitalisation costs of €6100–€8300 per adult patient, resulting in 20–28 million euros annually in The Netherlands. The highest arithmetic mean hospitalisation costs per patient were found in the 45–64 year age group. These influenza burden estimates could be used for future influenza cost-effectiveness and impact studies.

Suggested Citation

  • Sierk D. Marbus & Valentijn A. Schweitzer & Geert H. Groeneveld & Jan J. Oosterheert & Peter M. Schneeberger & Wim Hoek & Jaap T. Dissel & Arianne B. Gageldonk-Lafeber & Marie-Josée Mangen, 2020. "Incidence and costs of hospitalized adult influenza patients in The Netherlands: a retrospective observational study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(5), pages 775-785, July.
    • Handle: RePEc:spr:eujhec:v:21:y:2020:i:5:d:10.1007_s10198-020-01172-1
    DOI: 10.1007/s10198-020-01172-1
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    References listed on IDEAS

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    1. Yinong Young-Xu & Robertus van Aalst & Ellyn Russo & Jason K H Lee & Ayman Chit, 2017. "The Annual Burden of Seasonal Influenza in the US Veterans Affairs Population," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
    2. Carlo Federici & Marianna Cavazza & Francesco Costa & Claudio Jommi, 2018. "Health care costs of influenza-related episodes in high income countries: A systematic review," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-15, September.
    3. Gijs Hubben & Martin Bootsma & Michiel Luteijn & Diarmuid Glynn & David Bishai & Marc Bonten & Maarten Postma, 2011. "Modelling the Costs and Effects of Selective and Universal Hospital Admission Screening for Methicillin-Resistant Staphylococcus aureus," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-11, March.
    4. Jennifer Haas & Sebastian Braun & Peter Wutzler, 2016. "Burden of influenza in Germany: a retrospective claims database analysis for the influenza season 2012/2013," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(6), pages 669-679, July.
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    Cited by:

    1. Robert Susło & Piotr Pobrotyn & Lidia Brydak & Łukasz Rypicz & Urszula Grata-Borkowska & Jarosław Drobnik, 2021. "Seasonal Influenza and Low Flu Vaccination Coverage as Important Factors Modifying the Costs and Availability of Hospital Services in Poland: A Retrospective Comparative Study," IJERPH, MDPI, vol. 18(10), pages 1-15, May.
    2. Magdalena Świerczyńska & Dagmara M. Mirowska-Guzel & Edyta Pindelska, 2022. "Antiviral Drugs in Influenza," IJERPH, MDPI, vol. 19(5), pages 1-30, March.
    3. Mercè Soler-Font & Ignacio Aznar-Lou & Luca Basile & Núria Soldevila & Pere Godoy & Ana Martínez & Antoni Serrano-Blanco & Angela Domínguez & The Surveillance of Hospitalized Cases of Severe Influenza, 2022. "Costs and Factors Associated with Hospitalizations Due to Severe Influenza in Catalonia (2017–2020)," IJERPH, MDPI, vol. 19(22), pages 1-10, November.
    4. E.V. Popov, 2021. "Drivers of the Economy in the Context of the Coronavirus Pandemic," Journal of Applied Economic Research, Graduate School of Economics and Management, Ural Federal University, vol. 20(1), pages 5-30.

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    More about this item

    Keywords

    Influenza; Hospitalisation; Costs; Incidence;
    All these keywords.

    JEL classification:

    • I10 - Health, Education, and Welfare - - Health - - - General
    • I11 - Health, Education, and Welfare - - Health - - - Analysis of Health Care Markets

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