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Risk of Cancer in Association with Ranitidine and Nizatidine vs Other H2 Blockers: Analysis of the Japan Medical Data Center Claims Database 2005–2018

Author

Listed:
  • Masao Iwagami

    (University of Tsukuba
    London School of Hygiene and Tropical Medicine)

  • Ryosuke Kumazawa

    (The University of Tokyo)

  • Yoshihisa Miyamoto

    (The University of Tokyo)

  • Yuri Ito

    (Osaka Medical College)

  • Miho Ishimaru

    (University of Tsukuba)

  • Kojiro Morita

    (University of Tsukuba)

  • Shota Hamada

    (Association for Health Economics Research and Social Insurance and Welfare)

  • Nanako Tamiya

    (University of Tsukuba)

  • Hideo Yasunaga

    (London School of Hygiene and Tropical Medicine)

Abstract

Introduction In September 2019, ranitidine and nizatidine were suggested to contain N-nitrosodimethylamine, a carcinogenic substance. People have since been concerned about the potential impact of ranitidine/nizatidine use on the risk of cancer. Objective The objective of this study was to investigate the risk of cancer among people receiving ranitidine or nizatidine compared with other histamine 2 receptor antagonists (H2 blockers) [cimetidine, famotidine, roxatidine, and lafutidine]. Methods In the Japan Medical Data Center claims database (comprising people aged 730 DDDs. Conclusions We found no evidence that ranitidine/nizatidine is associated with an increased risk of cancer, although further studies with more accurate measurement of exposure, inclusion of older people, and longer follow-up may be needed.

Suggested Citation

  • Masao Iwagami & Ryosuke Kumazawa & Yoshihisa Miyamoto & Yuri Ito & Miho Ishimaru & Kojiro Morita & Shota Hamada & Nanako Tamiya & Hideo Yasunaga, 2021. "Risk of Cancer in Association with Ranitidine and Nizatidine vs Other H2 Blockers: Analysis of the Japan Medical Data Center Claims Database 2005–2018," Drug Safety, Springer, vol. 44(3), pages 361-371, March.
    • Handle: RePEc:spr:drugsa:v:44:y:2021:i:3:d:10.1007_s40264-020-01024-0
    DOI: 10.1007/s40264-020-01024-0
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    Cited by:

    1. Chun-Hsiang Wang & I-I Chen & Chung-Hung Chen & Yuan-Tsung Tseng, 2022. "Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study," IJERPH, MDPI, vol. 19(19), pages 1-16, September.

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