IDEAS home Printed from https://ideas.repec.org/a/spr/aphecp/v16y2018i6d10.1007_s40258-018-0409-3.html
   My bibliography  Save this article

Economic Implications of Pathogen Reduced and Bacterially Tested Platelet Components: A US Hospital Budget Impact Model

Author

Listed:
  • Katherine M. Prioli

    (Rutgers University)

  • Julie Katz Karp

    (Thomas Jefferson University Hospital)

  • Nina M. Lyons

    (Thomas Jefferson University)

  • Vera Chrebtow

    (Cerus Corporation)

  • Jay H. Herman

    (Thomas Jefferson University Hospital)

  • Laura T. Pizzi

    (Rutgers University)

Abstract

Background US FDA draft guidance includes pathogen reduction (PR) or secondary rapid bacterial testing (RT) in its recommendations for mitigating risk of platelet component (PC) bacterial contamination. An interactive budget impact model was created for hospitals to use when considering these technologies. Methods A Microsoft Excel model was built and populated with base-case costs and probabilities identified through literature search and a survey of US hospital transfusion service directors. Annual costs of PC acquisition, testing, wastage, dispensing/transfusion, sepsis, shelf life, and reimbursement for a mid-sized hospital that purchases all of its PCs were compared for four scenarios: 100% conventional PCs (C-PC), 100% RT-PC, 100% PR-PC, and 50% RT-PC/50% PR-PC. Results Annual total costs were US$3.64, US$3.67, and US$3.96 million when all platelets were C-PC, RT-PC, or PR-PC, respectively, or US$3.81 million in the 50% RT-PC/50% PR-PC scenario. The annual net cost of PR-PC, obtained by subtracting annual reimbursements from annual total costs, is 6.18% above that of RT-PC. Maximum usable shelf lives for C-PC, RT-PC, and PR-PC are 3.0, 5.0, and 3.6 days, respectively; hospitals obtain PR-PC components earliest at 1.37 days. Conclusion The model predicts minimal cost increase for PR-PC versus RT-PC, including cost offsets such as elimination of bacterial detection and irradiation, and reimbursement. Additional safety provided by PR, including risk mitigation of transfusion-transmission of a broad spectrum of viruses, parasites, and emerging pathogens, may justify this increase. Effective PC shelf life may increase with RT, but platelets can be available sooner with PR due to elimination of bacterial detection, depending on blood center logistics.

Suggested Citation

  • Katherine M. Prioli & Julie Katz Karp & Nina M. Lyons & Vera Chrebtow & Jay H. Herman & Laura T. Pizzi, 2018. "Economic Implications of Pathogen Reduced and Bacterially Tested Platelet Components: A US Hospital Budget Impact Model," Applied Health Economics and Health Policy, Springer, vol. 16(6), pages 889-899, December.
    • Handle: RePEc:spr:aphecp:v:16:y:2018:i:6:d:10.1007_s40258-018-0409-3
    DOI: 10.1007/s40258-018-0409-3
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40258-018-0409-3
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40258-018-0409-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dillon, Mary & Vauhkonen, Ilmari & Arvas, Mikko & Ihalainen, Jarkko & Vilkkumaa, Eeva & Oliveira, Fabricio, 2023. "Supporting platelet inventory management decisions: What is the effect of extending platelets’ shelf life?," European Journal of Operational Research, Elsevier, vol. 310(2), pages 640-654.
    2. Patrick R. LaFontaine & Jing Yuan & Katherine M. Prioli & Priti Shah & Jay H. Herman & Laura T. Pizzi, 2021. "Economic Analyses of Pathogen-Reduction Technologies in Blood Transfusion: A Systematic Literature Review," Applied Health Economics and Health Policy, Springer, vol. 19(4), pages 487-499, July.
    3. Paul Mintz, 2019. "Comment on: “Economic Implications of Pathogen Reduced and Bacterially Tested Platelet Components: A US Hospital Budget Impact Model”," Applied Health Economics and Health Policy, Springer, vol. 17(2), pages 257-258, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:aphecp:v:16:y:2018:i:6:d:10.1007_s40258-018-0409-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.