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The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome

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Listed:
  • Phuti Choshi
  • Sarah Pedretti
  • Tafadzwa Chimbetete
  • Rama Gangula
  • Muki Shey
  • Cari Stek
  • Rachel P J Lai
  • Robert Wilkinson
  • Graeme Meintjes
  • Elizabeth Phillips
  • Jonny Peter

Abstract

Genetic associations within the human leukocyte antigen (HLA) gene complex and linked genes in TB-IRIS outcomes remains population specific and not well understood. Here, we conducted a study including well characterised HIV-TB coinfected patients with (n = 86) and without (n = 124) TB-IRIS from the randomized, double-blind, prophylactic prednisone trial (PredART study) with HLA, ERAP and KIR genotyping data. We confirmed the association of TB-IRIS with lower CD4 counts pre-ART initiation. We identified nine classical class I and II HLA alleles protective against TB-IRIS, while four alleles were linked to increased risk. Associations ranged from strongly protective (HLA-DQB1*05:01, OR: 0.07, 95%CI: 0.02-0.28, Pc

Suggested Citation

  • Phuti Choshi & Sarah Pedretti & Tafadzwa Chimbetete & Rama Gangula & Muki Shey & Cari Stek & Rachel P J Lai & Robert Wilkinson & Graeme Meintjes & Elizabeth Phillips & Jonny Peter, 2025. "The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome," PLOS Pathogens, Public Library of Science, vol. 21(9), pages 1-8, September.
    • Handle: RePEc:plo:ppat00:1013497
    DOI: 10.1371/journal.ppat.1013497
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