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Enhancing daily oral PrEP adherence with digital communications: Protocol for a systematic review and meta-analysis

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  • Julien Brisson
  • Mariangela Castro-Arteaga
  • Dorothy Apedaile
  • Amaya Perez-Brumer

Abstract

Introduction: Pre-exposure prophylaxis (PrEP) stands as an effective tool in preventing HIV transmission among individuals at risk of HIV infection. However, the effectiveness of daily oral PrEP is contingent on the adherence of its users, which can pose a challenge for many individuals. Various studies have explored different interventions aimed at bolstering PrEP adherence. One recurring type of intervention revolves around digital communication (e.g., SMS, mobile applications) to send reminders for PrEP usage. The objective of our systematic review and meta-analysis is to address the following research question: What is the effectiveness of digital communication interventions in enhancing daily oral PrEP adherence among individuals at a heightened risk of HIV infection? This paper presents our study protocol. Method and analysis: We will conduct searches across four health-related databases: Embase, PubMed, Web of Science, and PsycINFO. We will also explore other sources, including clinical trials registries and grey literature. Our search will be restricted to original randomized controlled trials published in English, French, and Spanish conducted since 2012, when PrEP was approved, to today. To ensure rigor, three reviewers will perform the systematic review and meta-analysis. This systematic review will adhere to the guidelines outlined in the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our primary outcome of interest is proper daily oral PrEP adherence, which we will measure using association metrics (e.g., odds ratios). Discussion: This review will offer insights into the effectiveness of utilizing digital communication methods to assist individuals at risk of HIV in improving their PrEP adherence. Protocol registration number: International Prospective Register for Systematic Reviews (PROSPERO) number CRD42023471269.

Suggested Citation

  • Julien Brisson & Mariangela Castro-Arteaga & Dorothy Apedaile & Amaya Perez-Brumer, 2024. "Enhancing daily oral PrEP adherence with digital communications: Protocol for a systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0313322
    DOI: 10.1371/journal.pone.0313322
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    References listed on IDEAS

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    1. Jyoti Belur & Lisa Tompson & Amy Thornton & Miranda Simon, 2021. "Interrater Reliability in Systematic Review Methodology: Exploring Variation in Coder Decision-Making," Sociological Methods & Research, , vol. 50(2), pages 837-865, May.
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