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Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital

Author

Listed:
  • Robert Sinto
  • Khie Chen Lie
  • Siti Setiati
  • Suhendro Suwarto
  • Erni J Nelwan
  • Mulya Rahma Karyanti
  • Anis Karuniawati
  • Dean Handimulya Djumaryo
  • Ari Prayitno
  • Sumariyono Sumariyono
  • Mike Sharland
  • Catrin E Moore
  • Raph L Hamers
  • Nicholas P J Day
  • Direk Limmathurotsakul

Abstract

Background: Little is known about diagnostic and antibiotic use practices in low and middle-income countries (LMICs) before and during COVID-19 pandemic. This information is crucial for monitoring and evaluation of diagnostic and antimicrobial stewardships in healthcare facilities. Methods: We linked and analyzed routine databases of hospital admission, microbiology laboratory and drug dispensing of Indonesian National Referral Hospital from 2019 to 2020. Patients were classified as COVID-19 cases if their SARS-CoV-2 RT-PCR result were positive. Blood culture (BC) practices and time to discontinuation of parenteral antibiotics among inpatients who received a parenteral antibiotic for at least four consecutive days were used to assess diagnostic and antibiotic use practices, respectively. Fine and Grey subdistribution hazard model was used. Results: Of 1,311 COVID-19 and 58,917 non-COVID-19 inpatients, 333 (25.4%) and 18,837 (32.0%) received a parenteral antibiotic for at least four consecutive days. Proportion of patients having BC taken within ±1 calendar day of parenteral antibiotics being started was higher in COVID-19 than in non-COVID-19 patients (21.0% [70/333] vs. 18.7% [3,529/18,837]; p

Suggested Citation

  • Robert Sinto & Khie Chen Lie & Siti Setiati & Suhendro Suwarto & Erni J Nelwan & Mulya Rahma Karyanti & Anis Karuniawati & Dean Handimulya Djumaryo & Ari Prayitno & Sumariyono Sumariyono & Mike Sharla, 2024. "Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0297405
    DOI: 10.1371/journal.pone.0297405
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    1. Neal J Russell & Wolfgang Stöhr & Nishad Plakkal & Aislinn Cook & James A Berkley & Bethou Adhisivam & Ramesh Agarwal & Nawshad Uddin Ahmed & Manica Balasegaram & Daynia Ballot & Adrie Bekker & Eitan , 2023. "Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)," PLOS Medicine, Public Library of Science, vol. 20(6), pages 1-34, June.
    2. Timothy R Walsh & Ana C Gales & Ramanan Laxminarayan & Philippa C Dodd, 2023. "Antimicrobial Resistance: Addressing a Global Threat to Humanity," PLOS Medicine, Public Library of Science, vol. 20(7), pages 1-4, July.
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    1. Timothy R Walsh & Ana C Gales & Ramanan Laxminarayan & Philippa C Dodd, 2023. "Antimicrobial Resistance: Addressing a Global Threat to Humanity," PLOS Medicine, Public Library of Science, vol. 20(7), pages 1-4, July.

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