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Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

Author

Listed:
  • Neal J Russell
  • Wolfgang Stöhr
  • Nishad Plakkal
  • Aislinn Cook
  • James A Berkley
  • Bethou Adhisivam
  • Ramesh Agarwal
  • Nawshad Uddin Ahmed
  • Manica Balasegaram
  • Daynia Ballot
  • Adrie Bekker
  • Eitan Naaman Berezin
  • Davide Bilardi
  • Suppawat Boonkasidecha
  • Cristina G Carvalheiro
  • Neema Chami
  • Suman Chaurasia
  • Sara Chiurchiu
  • Viviane Rinaldi Favarin Colas
  • Simon Cousens
  • Tim R Cressey
  • Ana Carolina Dantas de Assis
  • Tran Minh Dien
  • Yijun Ding
  • Nguyen Trong Dung
  • Han Dong
  • Angela Dramowski
  • Madhusudhan DS
  • Ajay Dudeja
  • Jinxing Feng
  • Youri Glupczynski
  • Srishti Goel
  • Herman Goossens
  • Doan Thi Huong Hao
  • Mahmudul Islam Khan
  • Tatiana Munera Huertas
  • Mohammad Shahidul Islam
  • Daniel Jarovsky
  • Nathalie Khavessian
  • Meera Khorana
  • Angeliki Kontou
  • Tomislav Kostyanev
  • Premsak Laoyookhon
  • Sorasak Lochindarat
  • Mattias Larsson
  • Maia De Luca
  • Surbhi Malhotra-Kumar
  • Nivedita Mondal
  • Nitu Mundhra
  • Philippa Musoke
  • Marisa M Mussi-Pinhata
  • Ruchi Nanavati
  • Firdose Nakwa
  • Sushma Nangia
  • Jolly Nankunda
  • Alessandra Nardone
  • Borna Nyaoke
  • Christina W Obiero
  • Maxensia Owor
  • Wang Ping
  • Kanchana Preedisripipat
  • Shamim Qazi
  • Lifeng Qi
  • Tanusha Ramdin
  • Amy Riddell
  • Lorenza Romani
  • Praewpan Roysuwan
  • Robin Saggers
  • Emmanuel Roilides
  • Samir K Saha
  • Kosmas Sarafidis
  • Valerie Tusubira
  • Reenu Thomas
  • Sithembiso Velaphi
  • Tuba Vilken
  • Xiaojiao Wang
  • Yajuan Wang
  • Yonghong Yang
  • Liu Zunjie
  • Sally Ellis
  • Julia A Bielicki
  • A Sarah Walker
  • Paul T Heath
  • Mike Sharland

Abstract

Background: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design. Methods and findings: Hospitalized infants

Suggested Citation

  • Neal J Russell & Wolfgang Stöhr & Nishad Plakkal & Aislinn Cook & James A Berkley & Bethou Adhisivam & Ramesh Agarwal & Nawshad Uddin Ahmed & Manica Balasegaram & Daynia Ballot & Adrie Bekker & Eitan , 2023. "Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)," PLOS Medicine, Public Library of Science, vol. 20(6), pages 1-34, June.
    • Handle: RePEc:plo:pmed00:1004179
    DOI: 10.1371/journal.pmed.1004179
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    Cited by:

    1. Robert Sinto & Khie Chen Lie & Siti Setiati & Suhendro Suwarto & Erni J Nelwan & Mulya Rahma Karyanti & Anis Karuniawati & Dean Handimulya Djumaryo & Ari Prayitno & Sumariyono Sumariyono & Mike Sharla, 2024. "Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-14, March.
    2. Timothy R Walsh & Ana C Gales & Ramanan Laxminarayan & Philippa C Dodd, 2023. "Antimicrobial Resistance: Addressing a Global Threat to Humanity," PLOS Medicine, Public Library of Science, vol. 20(7), pages 1-4, July.

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