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Organization of two kinesins in a two-dimensional microtubule network

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  • Jesús M Bergues
  • Fernando Falo

Abstract

In intracellular active transport, molecular motors are responsible for moving biological cargo along networks of microtubules that serve as scaffolds. Cargo dynamics can be modified by different features of microtubule networks such as geometry, density, orientation modifications. Also, the dynamical behaviour of the molecular motors is determined by the microtubule network and by the individual and/or collective action of the motors. For example, unlike single kinesins, the mechanistic behavior of multiple kinesins varies from one experiment to another. However, the reasons for this experimental variability are unknown. Here we show theoretically how non-radial and quasi-radial microtubule architectures modify the collective behavior of two kinesins attached on a cargo. We found out under which structural conditions transport is most efficient and the most likely way in which kinesins are organized in active transport. In addition, with motor activity, mean intermotor distance and motor organization, we determined the character of the collective interaction of the kinesins during transport. Our results demonstrate that two-dimensional microtubule structures promote branching due to crossovers that alter directionality in cargo movement and may provide insight into the collective organization of the motors. Our article offers a perspective to analyze how the two-dimensional network can modify the cargo-motor dynamics for the case in which multiple motors move in different directions as in the case of kinesin and dynein.

Suggested Citation

  • Jesús M Bergues & Fernando Falo, 2024. "Organization of two kinesins in a two-dimensional microtubule network," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-17, March.
  • Handle: RePEc:plo:pone00:0295652
    DOI: 10.1371/journal.pone.0295652
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    References listed on IDEAS

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    2. Emmanuel Derivery & Carole Seum & Alicia Daeden & Sylvain Loubéry & Laurent Holtzer & Frank Jülicher & Marcos Gonzalez-Gaitan, 2015. "Polarized endosome dynamics by spindle asymmetry during asymmetric cell division," Nature, Nature, vol. 528(7581), pages 280-285, December.
    3. Andrew T. Lombardo & Shane R. Nelson & M. Yusuf Ali & Guy G. Kennedy & Kathleen M. Trybus & Sam Walcott & David M. Warshaw, 2017. "Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
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    5. N. J. Carter & R. A. Cross, 2005. "Mechanics of the kinesin step," Nature, Nature, vol. 435(7040), pages 308-312, May.
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