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Normalization in mouse primary visual cortex

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  • Zaina A Zayyad
  • John H R Maunsell
  • Jason N MacLean

Abstract

When multiple stimuli appear together in the receptive field of a visual cortical neuron, the response is typically close to the average of that neuron’s response to each individual stimulus. The departure from a linear sum of each individual response is referred to as normalization. In mammals, normalization has been best characterized in the visual cortex of macaques and cats. Here we study visually evoked normalization in the visual cortex of awake mice using imaging of calcium indicators in large populations of layer 2/3 (L2/3) V1 excitatory neurons and electrophysiological recordings across layers in V1. Regardless of recording method, mouse visual cortical neurons exhibit normalization to varying degrees. The distributions of normalization strength are similar to those described in cats and macaques, albeit slightly weaker on average.

Suggested Citation

  • Zaina A Zayyad & John H R Maunsell & Jason N MacLean, 2023. "Normalization in mouse primary visual cortex," PLOS ONE, Public Library of Science, vol. 18(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0295140
    DOI: 10.1371/journal.pone.0295140
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    References listed on IDEAS

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    1. Supratim Ray & Amy M Ni & John H R Maunsell, 2013. "Strength of Gamma Rhythm Depends on Normalization," PLOS Biology, Public Library of Science, vol. 11(2), pages 1-12, February.
    2. repec:plo:pone00:0004651 is not listed on IDEAS
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