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Association of tumor necrosis factor-α-308G/A polymorphism with the risk of obstructive sleep apnea: A meta-analysis of 14 case-control studies

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Listed:
  • Zhenlian Zhang
  • Dilihumaier Duolikun
  • Tingting Dang
  • Yuanyuan Wang
  • Lijuan Ma
  • Xueyun Ma
  • Qiaoling Yao

Abstract

Although numerous studies have suggested the association between TNF-α-308G/A polymorphism and susceptibility to obstructive sleep apnea (OSA), the results remained controversial and ambiguous. We performed the present meta-analysis to derive a more precise estimation.The PubMed, Embase, Cochrane library, Web of Science, China National Knowledge Infrastructure, Wanfang databases, and Weipu databases (until January 8, 2022) were accessed to retrieve relevant articles. Pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated using the STATA statistical software.Totally, fourteen studies involving 2595 cases and 2579 controls were enrolled in this meta-analysis. Pooled results demonstrated significant association between TNF-α-308G/A polymorphism and OSA risk for the overall population(allele model:OR = 1.87 [1.47, 2.38] (n = 14), dominant model: OR = 1.88[1.48, 2.39] (n = 14), recessive model:OR = 2.83 [2.00, 4.00] (n = 11), homozygous model:OR = 3.30 [2.32, 4.68] (n = 11), and heterozygous model:OR = 1.67 [1.36, 2.06] (n = 14); P

Suggested Citation

  • Zhenlian Zhang & Dilihumaier Duolikun & Tingting Dang & Yuanyuan Wang & Lijuan Ma & Xueyun Ma & Qiaoling Yao, 2023. "Association of tumor necrosis factor-α-308G/A polymorphism with the risk of obstructive sleep apnea: A meta-analysis of 14 case-control studies," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0290239
    DOI: 10.1371/journal.pone.0290239
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    References listed on IDEAS

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    1. Anyuan Zhong & Xiaolu Xiong & Huajun Xu & Minhua Shi, 2014. "An Updated Meta-Analysis of the Association between Tumor Necrosis Factor-α -308G/A Polymorphism and Obstructive Sleep Apnea-Hypopnea Syndrome," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-6, September.
    2. Yanping Wu & Chao Cao & Yinfang Wu & Chao Zhang & Chen Zhu & Songmin Ying & Zhihua Chen & Huahao Shen & Wen Li, 2014. "TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
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