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TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies

Author

Listed:
  • Yanping Wu
  • Chao Cao
  • Yinfang Wu
  • Chao Zhang
  • Chen Zhu
  • Songmin Ying
  • Zhihua Chen
  • Huahao Shen
  • Wen Li

Abstract

Objective: The aim of our study was to investigate the association between the TNF-α-308G/A polymorphism and obstructive sleep apnea syndrome (OSAS). Method: The Medline, Web of Science, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Cochrane Central Register of Controlled Trials were searched. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to study TNF-α-308G/A polymorphism and risk of OSAS. Result: 10 case-control studies were included in our meta-analysis. The results from our study showed that the TNF-α-308G/A polymorphism was significantly associated with risk of OSAS (A vs. G: OR = 1.67, 95% CI = 1.43–1.95). In the subgroup analysis by ethnicity, the statistical similar results were observed both in European (A vs. G: OR = 1.68, 95% CI = 1.35–2.08) and Asian population (A vs. G: OR = 2.02, 95% CI = 1.50–2.71). When stratified by age, a significantly increased risk was observed in adult carries A allele compared with G allele (OR = 1.79, 95% CI = 1.50–2.13), whereas no association was found in children (OR = 1.09, 95% CI = 0.70–1.69). Conclusion: Our study suggested that the TNF-α- 308G/A polymorphism contributed to the susceptibility to the risk of OSAS. Additional well-designed large studies are needed to validate our findings.

Suggested Citation

  • Yanping Wu & Chao Cao & Yinfang Wu & Chao Zhang & Chen Zhu & Songmin Ying & Zhihua Chen & Huahao Shen & Wen Li, 2014. "TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0106183
    DOI: 10.1371/journal.pone.0106183
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    Cited by:

    1. Zhenlian Zhang & Dilihumaier Duolikun & Tingting Dang & Yuanyuan Wang & Lijuan Ma & Xueyun Ma & Qiaoling Yao, 2023. "Association of tumor necrosis factor-α-308G/A polymorphism with the risk of obstructive sleep apnea: A meta-analysis of 14 case-control studies," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-11, August.

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