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Influences of age and gender on operative risks following carotid endarterectomy: A systematic review and meta-analysis

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  • Sothida Nantakool
  • Busaba Chuatrakoon
  • Saritphat Orrapin
  • Rachel Leung
  • Dominic P J Howard
  • Amaraporn Rerkasem
  • José G B Derraik
  • Kittipan Rerkasem

Abstract

Objectives: This review aims to undertake a comprehensive review of the literature and investigate associations of age and gender on 30 days post carotid endarterectomy (CEA) and up to 5 years post CEA stroke, death, and combined stroke and death. Design: A systematic review and meta-analysis. Methods: Three main electronic databases including the Cochrane Library, MEDLINE, and Embase were searched from their inception to July 2022. Studies examining operative risks (i.e., stroke, death, and combined stroke and death following CEA) linked to age or gender were included. Two independent reviewers were responsible for study selection, quality assessment, and data extraction. Odds ratio (OR) and 95% confidence interval (CI) of all outcomes were calculated. Results: 44609 studies were retrieved from the search. There were 127 eligible studies (80 studies of age, 72 studies of gender, 25 studies of age and gender) for pooling in the meta-analysis. With regards to stroke and death risks within 30 days post CEA; patients aged ≥75 had higher death (OR 1.38; 95% CI 1.10–1.75) than patients aged

Suggested Citation

  • Sothida Nantakool & Busaba Chuatrakoon & Saritphat Orrapin & Rachel Leung & Dominic P J Howard & Amaraporn Rerkasem & José G B Derraik & Kittipan Rerkasem, 2023. "Influences of age and gender on operative risks following carotid endarterectomy: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0285540
    DOI: 10.1371/journal.pone.0285540
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    1. Fisher, E.S. & Malenka, D.J. & Solomon, N.A. & Bubolz, T.A. & Whaley, F.S. & Wennberg, J.E., 1989. "Risk of carotid endarterectomy in the elderly," American Journal of Public Health, American Public Health Association, vol. 79(12), pages 1617-1620.
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