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Oral aspirin for preventing colorectal adenoma recurrence: A systematic review and network meta-analysis of randomized controlled trials

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  • Khanh Dinh Hoang
  • Jin-Hua Chen
  • Tsai-Wei Huang
  • Yi-No Kang
  • Chiehfeng Chen

Abstract

Colorectal adenomas have the potential of malignant transformation if left untreated. Multiple randomized controlled trials have been performed to evaluate the efficacy of aspirin in preventing colorectal adenoma recurrence in a population with a history of colorectal adenoma but not colorectal cancer, however, the relationship between aspirin dose and colorectal adenoma recurrence remains unclear. We conducted pairwise meta-analysis, meta-regression, trial sequential analysis, and network meta-analysis of all eligible studies. The ROB 2.0 tool was used to assess the risk of bias in the studies. The confidence in network meta-analysis (CINeMA) approach was used to evaluate the confidence of the network meta-analysis results. The network meta-analysis included eight RCTs (nine reports), comprising four on aspirin (low or high dose) alone and four on aspirin combined with another medication, all compared with placebo. In the network meta-analysis, low-dose aspirin (LDA

Suggested Citation

  • Khanh Dinh Hoang & Jin-Hua Chen & Tsai-Wei Huang & Yi-No Kang & Chiehfeng Chen, 2024. "Oral aspirin for preventing colorectal adenoma recurrence: A systematic review and network meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-17, March.
    • Handle: RePEc:plo:pone00:0279784
    DOI: 10.1371/journal.pone.0279784
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    References listed on IDEAS

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    1. Adriani Nikolakopoulou & Julian P T Higgins & Theodoros Papakonstantinou & Anna Chaimani & Cinzia Del Giovane & Matthias Egger & Georgia Salanti, 2020. "CINeMA: An approach for assessing confidence in the results of a network meta-analysis," PLOS Medicine, Public Library of Science, vol. 17(4), pages 1-19, April.
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