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Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Author

Listed:
  • Kanika Aggarwal
  • Aniruddha Agarwal
  • Nishant Jaiswal
  • Neha Dahiya
  • Alka Ahuja
  • Sarakshi Mahajan
  • Louis Tong
  • Mona Duggal
  • Meenu Singh
  • Rupesh Agrawal
  • Vishali Gupta

Abstract

Purpose: This study was performed to determine the occurrence of ocular surface manifestations in patients diagnosed with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: A systematic search of electronic databases i.e. PubMed, Web of Science, CINAHL, OVID and Google scholar was performed using a comprehensive search strategy. The searches were current through 31st May 2020. Pooled data from cross-sectional studies was used for meta-analysis and a narrative synthesis was conducted for studies where a meta-analysis was not feasible. Results: A total of 16 studies reporting 2347 confirmed COVID-19 cases were included. Pooled data showed that 11.64% of COVID-19 patients had ocular surface manifestations. Ocular pain (31.2%), discharge (19.2%), redness (10.8%), and follicular conjunctivitis (7.7%) were the main features. 6.9% patients with ocular manifestations had severe pneumonia. Viral RNA was detected from the ocular specimens in 3.5% patients. Conclusion: The most common reported ocular presentations of COVID-19 included ocular pain, redness, discharge, and follicular conjunctivitis. A small proportion of patients had viral RNA in their conjunctival/tear samples. The available studies show significant publication bias and heterogeneity. Prospective studies with methodical collection and data reporting are needed for evaluation of ocular involvement in COVID-19.

Suggested Citation

  • Kanika Aggarwal & Aniruddha Agarwal & Nishant Jaiswal & Neha Dahiya & Alka Ahuja & Sarakshi Mahajan & Louis Tong & Mona Duggal & Meenu Singh & Rupesh Agrawal & Vishali Gupta, 2020. "Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-20, November.
    • Handle: RePEc:plo:pone00:0241661
    DOI: 10.1371/journal.pone.0241661
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