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Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis

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Listed:
  • Paddy Ssentongo
  • Joseph A Lewcun
  • Xavier Candela
  • Anna E Ssentongo
  • Eustina G Kwon
  • Djibril M Ba
  • John S Oh
  • Forster Amponsah-Manu
  • Alicia C McDonald
  • Vernon M Chinchilli
  • David I Soybel
  • Daleela G Dodge

Abstract

Background: The survival rates from breast cancer in Africa are poor and yet the incidence rates are on the rise. In this study, we hypothesized that, in Africa, a continent with great disparities in socio-economic status, race, tumor biology, and cultural characteristics, the survival rates from breast cancer vary greatly based on region, tumor biology (hormone receptor), gender, and race. We aimed to conduct the first comprehensive systematic review and meta-analysis on region, gender, tumor-biology and race-specific 5-year breast cancer survival rates in Africa and compared them to 20-year survival trends in the United States. Methods: We searched MEDLINE, EMBASE, and Cochrane Library to identify studies on breast cancer survival in African published before October 17, 2018. Pooled 5-year survival rates of breast cancer were estimated by random-effects models. We explored sources of heterogeneity through subgroup meta-analyses and meta-regression. Results were reported as absolute difference (AD) in percentages. We compared the survival rates of breast cancer in Africa and the United States. Findings: There were 54 studies included, consisting of 18,970 breast cancer cases. There was substantial heterogeneity in the survival rates (mean 52.9%, range 7–91%, I2 = 99.1%; p for heterogeneity

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  • Paddy Ssentongo & Joseph A Lewcun & Xavier Candela & Anna E Ssentongo & Eustina G Kwon & Djibril M Ba & John S Oh & Forster Amponsah-Manu & Alicia C McDonald & Vernon M Chinchilli & David I Soybel & D, 2019. "Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0225039
    DOI: 10.1371/journal.pone.0225039
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    1. Tomi F Akinyemiju, 2012. "Socio-Economic and Health Access Determinants of Breast and Cervical Cancer Screening in Low-Income Countries: Analysis of the World Health Survey," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
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