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Effect of body composition on survival benefit of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: A comparison with sorafenib therapy

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  • Issei Saeki
  • Takahiro Yamasaki
  • Masaki Maeda
  • Takuro Hisanaga
  • Takuya Iwamoto
  • Toshihiko Matsumoto
  • Isao Hidaka
  • Tsuyoshi Ishikawa
  • Taro Takami
  • Isao Sakaida

Abstract

Aim: Sorafenib is used as a first-line treatment for advanced hepatocellular carcinoma (HCC). However, hepatic arterial infusion chemotherapy (HAIC) has also gained acceptance, but only in Japan. We explored the role of body composition as a factor affecting the survival benefit of HAIC compared to sorafenib for the treatment of advanced HCC. Methods: We conducted a retrospective study using the clinical records of 133 patients with advanced HCC treated either with HAIC or sorafenib. Prior to treatment induction, skeletal muscle index and visceral fat area (VFA) were measured at the third lumbar vertebral and umbilical levels, respectively, using computed tomography. Muscle depletion and high-VFA (H-VFA) were defined using published cut-offs. We analyzed clinical parameters, including body composition as prognostic factors. Results: In the HAIC group, multivariate analysis identified a positive response to HAIC (hazard ratio [HR], 0.438; p = 0.022), and conversion from HAIC to sorafenib (HR, 0.374; p = 0.008) as favorable prognostic factors for survival. In contrast, tumor number

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  • Issei Saeki & Takahiro Yamasaki & Masaki Maeda & Takuro Hisanaga & Takuya Iwamoto & Toshihiko Matsumoto & Isao Hidaka & Tsuyoshi Ishikawa & Taro Takami & Isao Sakaida, 2019. "Effect of body composition on survival benefit of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: A comparison with sorafenib therapy," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0218136
    DOI: 10.1371/journal.pone.0218136
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    1. Issei Saeki & Takahiro Yamasaki & Norikazu Tanabe & Takuya Iwamoto & Toshihiko Matsumoto & Yohei Urata & Isao Hidaka & Tsuyoshi Ishikawa & Taro Takami & Naoki Yamamoto & Koichi Uchida & Shuji Terai & , 2015. "A New Therapeutic Assessment Score for Advanced Hepatocellular Carcinoma Patients Receiving Hepatic Arterial Infusion Chemotherapy," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-14, May.
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