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A New Therapeutic Assessment Score for Advanced Hepatocellular Carcinoma Patients Receiving Hepatic Arterial Infusion Chemotherapy

Author

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  • Issei Saeki
  • Takahiro Yamasaki
  • Norikazu Tanabe
  • Takuya Iwamoto
  • Toshihiko Matsumoto
  • Yohei Urata
  • Isao Hidaka
  • Tsuyoshi Ishikawa
  • Taro Takami
  • Naoki Yamamoto
  • Koichi Uchida
  • Shuji Terai
  • Isao Sakaida

Abstract

Background & Aims: Hepatic arterial infusion chemotherapy (HAIC) is an option for treating advanced hepatocellular carcinoma (HCC). Because of the poor prognosis in HAIC non-responders, it is important to identify patients who may benefit from continuous HAIC treatment; however, there are currently no therapeutic assessment scores for this identification. Therefore, we aimed to establish a new therapeutic assessment score for such patients. Methods: We retrospectively analyzed 90 advanced HCC patients with elevated baseline alpha-fetoprotein (AFP) and/or des-gamma-carboxy prothrombin (DCP) levels and analyzed various parameters for their possible use as predictors of response and survival. AFP and DCP responses were assessed after half a course of HAIC (2 weeks); a positive-response was defined as a reduction of ≥ 20% from baseline. Results: Multivariate analysis identified DCP response (odds ratio 16.03, p

Suggested Citation

  • Issei Saeki & Takahiro Yamasaki & Norikazu Tanabe & Takuya Iwamoto & Toshihiko Matsumoto & Yohei Urata & Isao Hidaka & Tsuyoshi Ishikawa & Taro Takami & Naoki Yamamoto & Koichi Uchida & Shuji Terai & , 2015. "A New Therapeutic Assessment Score for Advanced Hepatocellular Carcinoma Patients Receiving Hepatic Arterial Infusion Chemotherapy," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0126649
    DOI: 10.1371/journal.pone.0126649
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    Cited by:

    1. Issei Saeki & Takahiro Yamasaki & Masaki Maeda & Takuro Hisanaga & Takuya Iwamoto & Toshihiko Matsumoto & Isao Hidaka & Tsuyoshi Ishikawa & Taro Takami & Isao Sakaida, 2019. "Effect of body composition on survival benefit of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: A comparison with sorafenib therapy," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.

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