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Selection on the Colombian paso horse's gaits has produced kinematic differences partly explained by the DMRT3 gene

Author

Listed:
  • Miguel Novoa-Bravo
  • Kim Jäderkvist Fegraeus
  • Marie Rhodin
  • Eric Strand
  • Luis Fernando García
  • Gabriella Lindgren

Abstract

The Colombian paso horse, the most important horse breed in Colombia, performs specific and particular gaits (paso fino, trocha, and Colombian trot), which display different footfall patterns and stride frequencies. The breed has been selected for gait and conformation for more than 50 years and we hypothesize that this selection has led to kinematic differences of the gaits that can be explained by different genetic variants. Hence, the aims of the study were: 1. To identify if there are any differences in the kinematic and genetic variants between the Colombian paso horse’s gaits. 2. To evaluate if and how much the gait differences were explained by the nonsense mutation in the DMRT3 gene and 3. To evaluate these results for selecting and controlling the horses gait performance. To test our hypotheses, kinematic data, microsatellites and DMRT3 genotypes for 187 Colombian paso horses were analyzed. The results indicated that there are significant kinematic and DMRT3 differences between the Colombian paso horse’s gaits, and those parameters can be used partially to select and control the horses gait performance. However, the DMRT3 gene does not play a major role in controlling the trocha and the Colombian trot gaits. Therefore, modifying genes likely influence these gaits. This study may serve as a foundation for implementing a genetic selection program in the Colombian paso horse and future gene discovery studies for locomotion pattern in horses.

Suggested Citation

  • Miguel Novoa-Bravo & Kim Jäderkvist Fegraeus & Marie Rhodin & Eric Strand & Luis Fernando García & Gabriella Lindgren, 2018. "Selection on the Colombian paso horse's gaits has produced kinematic differences partly explained by the DMRT3 gene," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-18, August.
    • Handle: RePEc:plo:pone00:0202584
    DOI: 10.1371/journal.pone.0202584
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    References listed on IDEAS

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    1. Kim Jäderkvist Fegraeus & Chameli Lawrence & Katrine Petäjistö & Maria K Johansson & Maja Wiklund & Christina Olsson & Leif Andersson & Lisa S Andersson & Knut H Røed & Carl-Fredrik Ihler & Eric Stran, 2017. "Lack of significant associations with early career performance suggest no link between the DMRT3 “Gait Keeper” mutation and precocity in Coldblooded trotters," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-10, May.
    2. Lisa S. Andersson & Martin Larhammar & Fatima Memic & Hanna Wootz & Doreen Schwochow & Carl-Johan Rubin & Kalicharan Patra & Thorvaldur Arnason & Lisbeth Wellbring & Göran Hjälm & Freyja Imsland & Jes, 2012. "Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice," Nature, Nature, vol. 488(7413), pages 642-646, August.
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    1. Kim Jäderkvist Fegraeus & Chameli Lawrence & Katrine Petäjistö & Maria K Johansson & Maja Wiklund & Christina Olsson & Leif Andersson & Lisa S Andersson & Knut H Røed & Carl-Fredrik Ihler & Eric Stran, 2017. "Lack of significant associations with early career performance suggest no link between the DMRT3 “Gait Keeper” mutation and precocity in Coldblooded trotters," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-10, May.

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