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Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice

Author

Listed:
  • Lisa S. Andersson

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden)

  • Martin Larhammar

    (Uppsala University, SE-75124 Uppsala, Sweden)

  • Fatima Memic

    (Uppsala University, SE-75124 Uppsala, Sweden)

  • Hanna Wootz

    (Uppsala University, SE-75124 Uppsala, Sweden)

  • Doreen Schwochow

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden)

  • Carl-Johan Rubin

    (Uppsala University, SE-75123 Uppsala, Sweden)

  • Kalicharan Patra

    (Uppsala University, SE-75124 Uppsala, Sweden)

  • Thorvaldur Arnason

    (Faculty of Land and Animal Resources, The Agricultural University of Iceland, IS-311 Borgarnes, Iceland)

  • Lisbeth Wellbring

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden)

  • Göran Hjälm

    (Uppsala University, SE-75123 Uppsala, Sweden)

  • Freyja Imsland

    (Uppsala University, SE-75123 Uppsala, Sweden)

  • Jessica L. Petersen

    (College of Veterinary Medicine, University of Minnesota)

  • Molly E. McCue

    (College of Veterinary Medicine, University of Minnesota)

  • James R. Mickelson

    (College of Veterinary Medicine, University of Minnesota)

  • Gus Cothran

    (College of Veterinary Medicine and Biomedical Sciences, Texas A&M University)

  • Nadav Ahituv

    (University of California San Francisco
    Institute for Human Genetics, University of California San Francisco)

  • Lars Roepstorff

    (Unit of Equine Studies, Swedish University of Agricultural Sciences, Uppsala, SE-75007 Sweden)

  • Sofia Mikko

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden)

  • Anna Vallstedt

    (Uppsala University, SE-75124 Uppsala, Sweden)

  • Gabriella Lindgren

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden)

  • Leif Andersson

    (Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
    Uppsala University, SE-75123 Uppsala, Sweden)

  • Klas Kullander

    (Uppsala University, SE-75124 Uppsala, Sweden)

Abstract

A premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses, and the Dmrt3 transcription factor is critical in the development of a coordinated locomotor network in mice, suggesting that it has an important role in configuring the spinal circuits that control stride.

Suggested Citation

  • Lisa S. Andersson & Martin Larhammar & Fatima Memic & Hanna Wootz & Doreen Schwochow & Carl-Johan Rubin & Kalicharan Patra & Thorvaldur Arnason & Lisbeth Wellbring & Göran Hjälm & Freyja Imsland & Jes, 2012. "Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice," Nature, Nature, vol. 488(7413), pages 642-646, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11399
    DOI: 10.1038/nature11399
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    Citations

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    Cited by:

    1. Miguel Novoa-Bravo & Kim Jäderkvist Fegraeus & Marie Rhodin & Eric Strand & Luis Fernando García & Gabriella Lindgren, 2018. "Selection on the Colombian paso horse's gaits has produced kinematic differences partly explained by the DMRT3 gene," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-18, August.
    2. Kim Jäderkvist Fegraeus & Chameli Lawrence & Katrine Petäjistö & Maria K Johansson & Maja Wiklund & Christina Olsson & Leif Andersson & Lisa S Andersson & Knut H Røed & Carl-Fredrik Ihler & Eric Stran, 2017. "Lack of significant associations with early career performance suggest no link between the DMRT3 “Gait Keeper” mutation and precocity in Coldblooded trotters," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-10, May.

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