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Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis

Author

Listed:
  • Matteo Fallico
  • Andrea Russo
  • Antonio Longo
  • Alfredo Pulvirenti
  • Teresio Avitabile
  • Vincenza Bonfiglio
  • Niccolò Castellino
  • Gilda Cennamo
  • Michele Reibaldi

Abstract

Background: Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. Objective: To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies. Methods: PubMed, Medline, Web of Science, Embase databases, and the Cochrane Library were searched up to April 2018 to identify studies that compared primary vitrectomy with and without ILM peeling for RRD with at least six months follow-up. Primary outcomes were the rate of postoperative ERM formation and mean best corrected visual acuity (BCVA) change after vitrectomy. Rate of recurrence of retinal detachment (RD) was assessed as secondary outcome. Risk ratios (RRs) with 95% confidence intervals (CIs) expressed pooled results for rate of ERM formation and rate of RD recurrence in ILM peeling and non-ILM peeling groups. Pooled results for BCVA change in the two groups were expressed as Weighted Mean Difference (WMD) with 95% CIs. Results: Nine studies, one of which was a randomized controlled trial (RCT), with a total number of 404 eyes in the ILM peeling group and 365 eyes in the non-ILM peeling group, were included. The analysis from pooled data indicated a significant lower rate of postoperative ERM formation in the ILM peeling group compared to the non-ILM peeling group (9 studies, 769 eyes, RR = 0.14; CI: 0.07 to 0.28; P

Suggested Citation

  • Matteo Fallico & Andrea Russo & Antonio Longo & Alfredo Pulvirenti & Teresio Avitabile & Vincenza Bonfiglio & Niccolò Castellino & Gilda Cennamo & Michele Reibaldi, 2018. "Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0201010
    DOI: 10.1371/journal.pone.0201010
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    References listed on IDEAS

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    1. Wei-Cheng Chang & Chin Lin & Cho-Hao Lee & Tzu-Ling Sung & Tao-Hsin Tung & Jorn-Hon Liu, 2017. "Vitrectomy with or without internal limiting membrane peeling for idiopathic epiretinal membrane: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-18, June.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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