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Two studies in one: A propensity-score-matched comparison of fingolimod versus interferons and glatiramer acetate using real-world data from the independent German studies, PANGAEA and PEARL

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  • Jonathan Alsop
  • Jennie Medin
  • Christian Cornelissen
  • Stefan Viktor Vormfelde
  • Tjalf Ziemssen

Abstract

Background: This study compared outcomes following fingolimod or BRACE treatments (beta-interferons/glatiramer acetate) in patients with active MS (≥ 1 relapse in the previous year) following previous BRACE treatment. Methods and findings: Patients with active MS who previously received BRACE were identified from German prospective, observational studies, PANGAEA and PEARL. A novel methodology was developed to compare outcomes between propensity-score-matched cohorts (3:1 ratio) from the independent single-arm studies. Patients in PANGAEA (n = 1287) experienced 48% fewer relapses per year than those in PEARL (n = 429; annualized relapse rate ratio: 0.52; p

Suggested Citation

  • Jonathan Alsop & Jennie Medin & Christian Cornelissen & Stefan Viktor Vormfelde & Tjalf Ziemssen, 2017. "Two studies in one: A propensity-score-matched comparison of fingolimod versus interferons and glatiramer acetate using real-world data from the independent German studies, PANGAEA and PEARL," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0173353
    DOI: 10.1371/journal.pone.0173353
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    1. Gisela Kobelt & Jenny Berg & Peter Lindgren & W. Elias & P. Flachenecker & M. Freidel & N. König & V. Limmroth & E. Straube, 2006. "Costs and quality of life of multiple sclerosis in Germany," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(2), pages 34-44, July.
    2. Gisela Kobelt & Jenny Berg & Peter Lindgren & Bengt Jönsson, 2006. "Costs and quality of life in multiple sclerosis in Europe: method of assessment and analysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(02), pages 5-13, July.
    3. Gisela Kobelt & Jenny Berg & Peter Lindgren & Bengt Jönsson, 2006. "Costs and quality of life in multiple sclerosis in Europe: method of assessment and analysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(2), pages 5-13, July.
    4. Gisela Kobelt & Jenny Berg & Peter Lindgren & W. Elias & P. Flachenecker & M. Freidel & N. König & V. Limmroth & E. Straube, 2006. "Costs and quality of life of multiple sclerosis in Germany," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(02), pages 34-44, July.
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