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Survival Analysis of Single Large (>5 cm) Hepatocellular Carcinoma Patients: BCLC A versus B

Author

Listed:
  • Yuri Cho
  • Dong Hyun Sinn
  • Su Jong Yu
  • Geum Youn Gwak
  • Ji Hoon Kim
  • Yang Jae Yoo
  • Dae Won Jun
  • Tae Yeob Kim
  • Hyo Young Lee
  • Eun Ju Cho
  • Jeong-Hoon Lee
  • Yoon Jun Kim
  • Jung-Hwan Yoon

Abstract

Background & Aims: Single large (>5 cm) hepatocellular carcinoma (HCC) is classified as Barcelona Liver Clinic (BCLC) stage early stage (A). Yet, controversies exist whether single large HCC can be considered as early stage. We have analyzed long-term outcome to see which stage is appropriate for these patients. Methods: From 2005 to 2006, 1,546 consecutive patients who were newly diagnosed as HCC (BCLC A or B) at four tertiary hospitals in Korea were analyzed. BCLC A was sub-classified into A1 (single 2–5 cm), A2 (2–3 nodules ≤3 cm), and A3 (single >5 cm). BCLC B1 included patients beyond-Milan criteria, and within up-to-7 criterion. Survival prediction between subgroupings (1: A1 + A2 + A3 vs. B1 and 2: A1 + A2 vs. A3 + B1) was compared based on c-index and Akaike information criterion (AIC). Results: The 5-year overall survival (OS) rate was 62.3, 58.6, 36.8, and 42.0% for A1, A2, A3 and B1, respectively. In multivariate Cox-regression analysis, OS was significantly different between A3 + B1 vs. A1 + A2 (hazard ratio [HR] 1.85; P

Suggested Citation

  • Yuri Cho & Dong Hyun Sinn & Su Jong Yu & Geum Youn Gwak & Ji Hoon Kim & Yang Jae Yoo & Dae Won Jun & Tae Yeob Kim & Hyo Young Lee & Eun Ju Cho & Jeong-Hoon Lee & Yoon Jun Kim & Jung-Hwan Yoon, 2016. "Survival Analysis of Single Large (>5 cm) Hepatocellular Carcinoma Patients: BCLC A versus B," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0165722
    DOI: 10.1371/journal.pone.0165722
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    References listed on IDEAS

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    1. Jian-Hong Zhong & Bang-De Xiang & Wen-Feng Gong & Yang Ke & Qin-Guo Mo & Liang Ma & Xing Liu & Le-Qun Li, 2013. "Comparison of Long-Term Survival of Patients with BCLC Stage B Hepatocellular Carcinoma after Liver Resection or Transarterial Chemoembolization," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
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