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PSCA rs2294008 Polymorphism with Increased Risk of Cancer

Author

Listed:
  • Peiliang Geng
  • Jianjun Li
  • Ning Wang
  • Juanjuan Ou
  • Ganfeng Xie
  • Chen Liu
  • Xiaoxin Zhao
  • Lisha Xiang
  • Yunmei Liao
  • Houjie Liang

Abstract

Background: Published data on the association between PSCA rs2294008 polymorphism and cancer risk have implicated inconclusive results. To determine the relationship and to precisely assess the effect size estimate of the association, we performed a meta-analysis. Methods: We searched published literature in Embase and PubMed databases using the search terms “PSCA”, “prostate stem cell antigen”, “variants”, “polymorphism”, “polymorphisms”, and “cancer”. A total of 21 eligible articles were retrieved, with 27, 197 cancer cases and 48, 237 controls. Results: On the whole, we found the association between PSCA rs2294008 polymorphism and cancer risk was statistically significant: TT vs CC: OR = 1.18, 95% CI, 1.10 to 1.27; TT + CT vs CC: OR = 1.08, 95% CI, 1.05 to 1.10; TT vs CT + CC: OR = 1.14, 95% CI, 1.07 to 1.21; T vs C: OR = 1.10, 95% CI, 1.06 to 1.14; CT vs CC: OR = 1.10, 95% CI, 1.06 to 1.13. Stratified analyses in cancer type and ethnicity showed similar results. Conclusions: Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.

Suggested Citation

  • Peiliang Geng & Jianjun Li & Ning Wang & Juanjuan Ou & Ganfeng Xie & Chen Liu & Xiaoxin Zhao & Lisha Xiang & Yunmei Liao & Houjie Liang, 2015. "PSCA rs2294008 Polymorphism with Increased Risk of Cancer," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0136269
    DOI: 10.1371/journal.pone.0136269
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    1. Wu Rongling & Bailian Li, 1999. "A Multiplicative-Epistatic Model for Analyzing Interspecific Differences in Outcrossing Species," Biometrics, The International Biometric Society, vol. 55(2), pages 355-365, June.
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    1. Xu-Ming Zhu & Wei-Feng Sun, 2017. "Association between matrix metalloproteinases polymorphisms and ovarian cancer risk: A meta-analysis and systematic review," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-16, September.

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