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A Serum Vitamin D Level

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  • Junli Zeng
  • Guannan Wu
  • Wen Yang
  • Xiaoling Gu
  • Wenjun Liang
  • Yanwen Yao
  • Yong Song

Abstract

Background: Low serum Vitamin D is considered to be associated with tuberculosis while the “dangerous” level was not clear. The aim of this study was to identify the association between tuberculosis and serum Vitamin D levels via synthesis of available evidence. Methods: A search of EMBASE, Medline, ISI Web of knowledge, and Pubmed was conducted. The number of subjects of tuberculosis and no-tuberculosis groups in four Vitamin D range. Meta-analyses were performed and presented by odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: A total of 15 studies involving 1440 cases and 2558 controls were included. A significantly increased risk of tuberculosis was found in two ranges: ≤ 12.5 nmol/L: pooled OR = 4.556, 95% CI = 2.200-9.435; 13-25 nmol/L: pooled OR = 3.797, 95% CI = 1.935-7.405. No statistically significant risk of tuberculosis was found in the range of 26–50 nmol/L (pooled OR = 1.561, 95% CI =0.997-2.442). In range 51–75 nmol/L, no positive association was found (pooled OR =1.160, 95% CI = 0.708-1.900). Conclusions: This study found that a serum Vitamin D level ≤ 25 nmol/L was significantly associated with an increased risk of tuberculosis while the range of 51–75 nmol/L was not. The range 26-50nmol/L posed potential high tuberculosis risk. Future large-scale, well-designed studies are needed to verify these results.

Suggested Citation

  • Junli Zeng & Guannan Wu & Wen Yang & Xiaoling Gu & Wenjun Liang & Yanwen Yao & Yong Song, 2015. "A Serum Vitamin D Level," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0126014
    DOI: 10.1371/journal.pone.0126014
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    Cited by:

    1. Mi Hyun Joo & Mi Ah Han & Sun Mi Park & Hwan Ho Shin, 2017. "Vitamin D Deficiency among Adults with History of Pulmonary Tuberculosis in Korea Based on a Nationwide Survey," IJERPH, MDPI, vol. 14(4), pages 1-10, April.
    2. Raffaele Domenici & Francesco Vierucci, 2022. "Exclusive Breastfeeding and Vitamin D Supplementation: A Positive Synergistic Effect on Prevention of Childhood Infections?," IJERPH, MDPI, vol. 19(5), pages 1-29, March.
    3. Ester Lilian Acen & Irene Andia Biraro & William Worodria & Moses L Joloba & Bill Nkeeto & Joseph Musaazi & David Patrick Kateete, 2021. "Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-17, June.

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