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Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis

Author

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  • Yanyan Wang
  • Yujie Zhang
  • Chi Pan
  • Feixia Ma
  • Suzhan Zhang

Abstract

Background: MicroRNA-21 (miRNA-21 or miR-21) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. Therefore, the present meta-analysis summarizes this evidence and evaluates the prognostic role of this gene in breast cancer. Methods: The meta-analysis was conducted by searching the databases of PubMed, EMBASE, Web of Science and Chinese database-China National Knowledge Infrastructure (CNKI). Data were extracted from studies that investigated the association between miR-21 expression and survival outcomes in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of miR-21 were calculated given a 95% confidence interval (CI). Results: Our meta-analysis identified a total of 10 studies involving 1,439 cases. Further investigation demonstrated that a high miR-21 expression can predict poor overall survival (OS) (HR = 2.57, 95% CI: 1.37—4.81, P = 0.003) and shortened disease-free/recurrence-free survival (DFS/RFS) (HR = 1.45, 95% CI: 1.16—1.82, P = 0.001) in breast cancer patients. Moreover, high miR-21 expression was significantly correlated with lowered OS in the Asian group (HR = 5.07, 95% CI: 2.89—8.92, P

Suggested Citation

  • Yanyan Wang & Yujie Zhang & Chi Pan & Feixia Ma & Suzhan Zhang, 2015. "Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0118647
    DOI: 10.1371/journal.pone.0118647
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    References listed on IDEAS

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    1. Jian Wang & Jiqing Zhao & Mengjing Shi & Yu Ding & Huiqin Sun & Fahuan Yuan & Zhongmin Zou, 2014. "Elevated Expression of miR-210 Predicts Poor Survival of Cancer Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    2. Xiaochun Xia & Baixia Yang & Xiaogang Zhai & Xiangyang Liu & Kang Shen & Zhijun Wu & Jing Cai, 2013. "Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    3. Wenjie Zhu & Binghe Xu, 2014. "MicroRNA-21 Identified as Predictor of Cancer Outcome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    4. Victor Ambros, 2004. "The functions of animal microRNAs," Nature, Nature, vol. 431(7006), pages 350-355, September.
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