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48-Week Efficacy and Safety of Dolutegravir Relative to Commonly Used Third Agents in Treatment-Naive HIV-1–Infected Patients: A Systematic Review and Network Meta-Analysis

Author

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  • Dipen A Patel
  • Sonya J Snedecor
  • Wing Yu Tang
  • Lavanya Sudharshan
  • Jessica W Lim
  • Robert Cuffe
  • Sonia Pulgar
  • Kim A Gilchrist
  • Rodrigo Refoios Camejo
  • Jennifer Stephens
  • Garrett Nichols

Abstract

Background: A network meta-analysis can provide estimates of relative efficacy for treatments not directly studied in head-to-head randomized controlled trials. We estimated the relative efficacy and safety of dolutegravir (DTG) versus third agents currently recommended by guidelines, including ritonavir-boosted atazanavir (ATV/r), ritonavir-boosted darunavir (DRV/r), efavirenz (EFV), cobicistat-boosted elvitegravir (EVG/c), ritonavir-boosted lopinavir (LPV/r), raltegravir (RAL), and rilpivirine (RPV), in treatment-naive HIV-1–infected patients. Methods: A systematic review of published literature was conducted to identify phase 3/4 randomized controlled clinical trials (up to August 2013) including at least one third agent of interest in combination with a backbone nucleoside reverse transcriptase inhibitor (NRTI) regimen. Bayesian fixed-effect network meta-analysis models adjusting for the type of nucleoside reverse transcriptase inhibitor backbone (tenofovir disoproxil fumarate/emtricitabine [TDF/FTC] or abacavir/lamivudine [ABC/3TC]) were used to evaluate week 48 efficacy (HIV-RNA suppression to

Suggested Citation

  • Dipen A Patel & Sonya J Snedecor & Wing Yu Tang & Lavanya Sudharshan & Jessica W Lim & Robert Cuffe & Sonia Pulgar & Kim A Gilchrist & Rodrigo Refoios Camejo & Jennifer Stephens & Garrett Nichols, 2014. "48-Week Efficacy and Safety of Dolutegravir Relative to Commonly Used Third Agents in Treatment-Naive HIV-1–Infected Patients: A Systematic Review and Network Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-10, September.
    • Handle: RePEc:plo:pone00:0105653
    DOI: 10.1371/journal.pone.0105653
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    References listed on IDEAS

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    2. Sofia Dias & Nicky J. Welton & Alex J. Sutton & A. E. Ades, 2013. "Evidence Synthesis for Decision Making 1," Medical Decision Making, , vol. 33(5), pages 597-606, July.
    3. Sofia Dias & Alex J. Sutton & A. E. Ades & Nicky J. Welton, 2013. "Evidence Synthesis for Decision Making 2," Medical Decision Making, , vol. 33(5), pages 607-617, July.
    4. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    5. Caitlyn T Solem & Sonya J Snedecor & Alexandra Khachatryan & Katherine Nedrow & Margaret Tawadrous & Richard Chambers & Seema Haider & Kit Simpson, 2014. "Cost of Treatment in a US Commercially Insured, HIV-1–Infected Population," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-8, May.
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