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Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis

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  • Jiang Chen
  • Jie Zhao
  • Rui Ma
  • Hui Lin
  • Xiao Liang
  • Xiujun Cai

Abstract

Backgrounds: Hepatocellular Carcinoma (HCC) is one of the most common malignancy of liver and HCC-related morbidity and mortality remains at high level. Researchers had investigated whether and how reduced E-cadherin expression impacted the prognosis of patients with HCC but the results reported by different teams remain inconclusive. Methods: A systematic literature search was performed in all available databases to retrieve eligible studies and identify all relevant data, which could be used to evaluate the correlation between reduced E-cadherin expression and clinicopathological features and prognosis for HCC patients. A fixed or random effects model was used in this meta-analysis to calculate the pooled odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CI). Results: Total 2439 patients in thirty studies matched the selection criteria. Aggregation of the data suggested that reduced E-cadherin expression in HCC patients correlated with poor 1-, 3- and 5-year overall survival. The combined ORs were 0.50 (n = 13 studies, 95% CI: 0.37–0.67, Z = 4.49, P

Suggested Citation

  • Jiang Chen & Jie Zhao & Rui Ma & Hui Lin & Xiao Liang & Xiujun Cai, 2014. "Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0103952
    DOI: 10.1371/journal.pone.0103952
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    References listed on IDEAS

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    1. Zhigang Chen & Xin He & Minyue Jia & Yang Liu & Dihong Qu & Dang Wu & Pin Wu & Chao Ni & Zhigang Zhang & Jun Ye & Jinghong Xu & Jian Huang, 2013. "β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
    2. Xin He & Zhigang Chen & Minyue Jia & Xiaoying Zhao, 2013. "Downregulated E-Cadherin Expression Indicates Worse Prognosis in Asian Patients with Colorectal Cancer: Evidence from Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
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