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β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis

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Listed:
  • Zhigang Chen
  • Xin He
  • Minyue Jia
  • Yang Liu
  • Dihong Qu
  • Dang Wu
  • Pin Wu
  • Chao Ni
  • Zhigang Zhang
  • Jun Ye
  • Jinghong Xu
  • Jian Huang

Abstract

Background: β-catenin plays a key role in the progression of colorectal cancer (CRC). However, its prognostic significance for patients with CRC remains controversial. Methodology: Identical search strategies were used to search relevant literatures in the PubMed, Embase and Web of Science databases. The correlation between β-catenin expression and clinicopathological features and prognosis was analyzed. Principal Findings: A total of 18 studies met the inclusion criteria, which comprised 3665 cases. Meta-analysis suggested that β-catenin overexpression in the nucleus was significantly associated with disease free survival (DFS) (n = 541 in 3 studies; HR = 1.87, 95% CI: 1.28–2.71; Z = 3.26; P = 0.001) and overall survival (OS) for CRC patients (n = 2630 in 10 studies; HR = 1.55, 95% CI: 1.12–2.14; Z = 2.62; P = 0.009). However, there was no significant association between β-catenin expression in the cytoplasm and OS (n = 1327 in 3 studies; HR = 1.04, 95% CI: 0.88–1.24, Z = 0.46, P = 0.643). The combined odds ratio (OR) of β-catenin in the nucleus indicated that β-catenin overexpression was associated with advanced stage CRC (n = 950 in 7 studies; OR = 0.71, 95% CI: 0.53–0.94; Z = 2.35; P = 0.019) and metastasis of CRC (n = 628 in 5 studies; OR = 0.49, 95% CI: 0.25–0.96, Z = 2.06, P = 0.039). β-catenin overexpression in the nucleus had no correlation with the tumor site (colon or rectum), differentiation grade, lymph node status or depth of invasion. The pooled ORs were 1.09 (95% CI: 0.41–2.91, Z = 0.18, P = 0.856), 1.27(95% CI: 0.76–2.10, Z = 0.92, P = 0.357), 0.71(95% CI: 0.46–1.09, Z = 1.58, P = 0.115) and 0.82(95% CI: 0.4–1.68, Z = 0.53, P = 0.594). Conclusions: This study showed that β-catenin overexpression in the nucleus, rather than in the cytoplasm, appeared to be associated with progress disease and a worse prognosis for CRC patients.

Suggested Citation

  • Zhigang Chen & Xin He & Minyue Jia & Yang Liu & Dihong Qu & Dang Wu & Pin Wu & Chao Ni & Zhigang Zhang & Jun Ye & Jinghong Xu & Jian Huang, 2013. "β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0063854
    DOI: 10.1371/journal.pone.0063854
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    Cited by:

    1. Jiang Chen & Jie Zhao & Rui Ma & Hui Lin & Xiao Liang & Xiujun Cai, 2014. "Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.
    2. Jiang Chen & Jinghua Liu & Renan Jin & Jiliang Shen & Yuelong Liang & Rui Ma & Hui Lin & Xiao Liang & Hong Yu & Xiujun Cai, 2014. "Cytoplasmic and/or Nuclear Expression of β-Catenin Correlate with Poor Prognosis and Unfavorable Clinicopathological Factors in Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-18, November.

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