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Serum Uric Acid Is Associated with Incident Chronic Kidney Disease in Middle-Aged Populations: A Meta-Analysis of 15 Cohort Studies

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  • Ping Zhu
  • Yan Liu
  • Lu Han
  • Gang Xu
  • Jian-min Ran

Abstract

Background: Mounting evidence indicates that elevated serum uric acid may increase the incidence of chronic kidney disease (CKD). Our goal was to systematically evaluate longitudinal cohort studies for the association of serum uric acid levels and incident CKD. Methods: We searched electronic databases and the reference lists of relevant articles. The primary outcome was incident CKD, which was defined as an eGFR less than 60 mL/min/1.73 m2 at the follow-up examination. Study-specific risk estimates were combined using random-effects models. The included studies were stratified into subgroups, and meta-regression analyses were performed. Results: Fifteen unique cohorts with a total of 99,205 individuals and 3,492 incident CKD cases were included. The relative risk of CKD was 1.22 (95% CI 1.16–1.28, I2 = 65.9%) per 1 mg/dL serum uric level increment. This positive association was consistently observed in subgroups stratified according to most of the study-level characteristics. The observed positive association was more pronounced among group with a mean age

Suggested Citation

  • Ping Zhu & Yan Liu & Lu Han & Gang Xu & Jian-min Ran, 2014. "Serum Uric Acid Is Associated with Incident Chronic Kidney Disease in Middle-Aged Populations: A Meta-Analysis of 15 Cohort Studies," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0100801
    DOI: 10.1371/journal.pone.0100801
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    1. Sanaz Sedaghat & Ewout J Hoorn & Frank J A van Rooij & Albert Hofman & Oscar H Franco & Jacqueline C M Witteman & Abbas Dehghan, 2013. "Serum Uric Acid and Chronic Kidney Disease: The Role of Hypertension," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
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