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Serum Uric Acid and Chronic Kidney Disease: The Role of Hypertension

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  • Sanaz Sedaghat
  • Ewout J Hoorn
  • Frank J A van Rooij
  • Albert Hofman
  • Oscar H Franco
  • Jacqueline C M Witteman
  • Abbas Dehghan

Abstract

Background: There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association. Methods: We included 2601 subjects aged 55 years and over from the Rotterdam Study. Serum uric acid and estimated glomerular filtration rate (eGFR) were assessed at baseline. After average 6.5 years of follow-up, second eGFR was assessed. CKD was defined as eGFR

Suggested Citation

  • Sanaz Sedaghat & Ewout J Hoorn & Frank J A van Rooij & Albert Hofman & Oscar H Franco & Jacqueline C M Witteman & Abbas Dehghan, 2013. "Serum Uric Acid and Chronic Kidney Disease: The Role of Hypertension," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0076827
    DOI: 10.1371/journal.pone.0076827
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    Cited by:

    1. Ping Zhu & Yan Liu & Lu Han & Gang Xu & Jian-min Ran, 2014. "Serum Uric Acid Is Associated with Incident Chronic Kidney Disease in Middle-Aged Populations: A Meta-Analysis of 15 Cohort Studies," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.

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