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Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China

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  • Ya Li Luo
  • Yu Li Cheng
  • Xiao Hui Gao
  • Shu Qin Tan
  • Jian Mei Li
  • Wei Wang
  • Qing Chen

Abstract

Background: The etiology of birth defects has been widely studied but is not yet fully clarified, previously published data had suggested that maternal age or parity maybe involved, but without consistent conclusions. Methods: A population-based, case-control study was nested in a cohort of perinatal infants born from 2010 to 2012 in Baoan District, Shenzhen. Four categories of isolated birth defects were defined as cases: congenital heart defects (CHD, n = 693), polydactyly (n = 352), cleft lip with or without palate (CL/P, n = 159) and equinovarus (n = 119). Controls were non-malformed infants (n = 11,307) randomly selected from the same area and period. Odds ratios (ORs) and the 95% confidence intervals (CIs) were computed by multivariable unconditional logistic regression analysis. Results: Young maternal age (

Suggested Citation

  • Ya Li Luo & Yu Li Cheng & Xiao Hui Gao & Shu Qin Tan & Jian Mei Li & Wei Wang & Qing Chen, 2013. "Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-6, November.
    • Handle: RePEc:plo:pone00:0081369
    DOI: 10.1371/journal.pone.0081369
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