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Elevated Alanine Aminotransferase Is Strongly Associated with Incident Metabolic Syndrome: A Meta-Analysis of Prospective Studies

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  • Zhengtao Liu
  • Shuping Que
  • Huaijun Ning
  • Linlin Wang
  • Tao Peng

Abstract

Background: The incidence of metabolic syndrome (MetS) is rapidly increasing worldwide and associated with alanine aminotransferase (ALT) activity. However, the impact of ALT activity on MetS incidence is inconsistent in published literature. We therefore estimated the association between elevated ALT activity and incident MetS through a meta-analysis of prospective cohort studies. Methods/Principal Findings: All published prospective cohort studies on the association between elevated ALT activity and incident MetS were retrieved from Pubmed, Embase, and the Institute for Scientific Information (ISI). In all, seven prospective cohort studies, with 31545 participants and 2873 cases of incident MetS were recruited. If there was insignificant heterogeneity (P-value>0.05 and I2

Suggested Citation

  • Zhengtao Liu & Shuping Que & Huaijun Ning & Linlin Wang & Tao Peng, 2013. "Elevated Alanine Aminotransferase Is Strongly Associated with Incident Metabolic Syndrome: A Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0080596
    DOI: 10.1371/journal.pone.0080596
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    1. Lamiaa Mobarak, 2019. "Effect of body mass index on Disease progression in Chronic Hepatitis B Patients," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 9(3), pages 62-65, January.
    2. Xuebing Zhang & Yiming Mu & Wenhua Yan & Jianming Ba & Hongmei Li, 2014. "Alanine Aminotransferase within Reference Range Is Associated with Metabolic Syndrome in Middle-Aged and Elderly Chinese Men and Women," IJERPH, MDPI, vol. 11(12), pages 1-10, December.
    3. Zhengtao Liu & Huaijun Ning & Shuping Que & Linlin Wang & Xue Qin & Tao Peng, 2014. "Complex Association between Alanine Aminotransferase Activity and Mortality in General Population: A Systematic Review and Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-19, March.
    4. Lamiaa Mobarak, 2019. "Effect of body mass index on Disease progression in Chronic Hepatitis B Patients," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 9(3), pages 1-4, January.

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