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Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified

Author

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  • Maria De Angelis
  • Maria Piccolo
  • Lucia Vannini
  • Sonya Siragusa
  • Andrea De Giacomo
  • Diana Isabella Serrazzanetti
  • Fernanda Cristofori
  • Maria Elisabetta Guerzoni
  • Marco Gobbetti
  • Ruggiero Francavilla

Abstract

This study aimed at investigating the fecal microbiota and metabolome of children with Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism (AD) in comparison to healthy children (HC). Bacterial tag-encoded FLX-titanium amplicon pyrosequencing (bTEFAP) of the 16S rDNA and 16S rRNA analyses were carried out to determine total bacteria (16S rDNA) and metabolically active bacteria (16S rRNA), respectively. The main bacterial phyla (Firmicutes, Bacteroidetes, Fusobacteria and Verrucomicrobia) significantly (P

Suggested Citation

  • Maria De Angelis & Maria Piccolo & Lucia Vannini & Sonya Siragusa & Andrea De Giacomo & Diana Isabella Serrazzanetti & Fernanda Cristofori & Maria Elisabetta Guerzoni & Marco Gobbetti & Ruggiero Franc, 2013. "Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    • Handle: RePEc:plo:pone00:0076993
    DOI: 10.1371/journal.pone.0076993
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    References listed on IDEAS

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    1. Anne Chao & John Bunge, 2002. "Estimating the Number of Species in a Stochastic Abundance Model," Biometrics, The International Biometric Society, vol. 58(3), pages 531-539, September.
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    1. Shih-Chen Fu & Chung-Han Lee & Hsiuying Wang, 2021. "Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome," IJERPH, MDPI, vol. 18(2), pages 1-13, January.
    2. Maria De Angelis & Eustacchio Montemurno & Maria Piccolo & Lucia Vannini & Gabriella Lauriero & Valentina Maranzano & Giorgia Gozzi & Diana Serrazanetti & Giuseppe Dalfino & Marco Gobbetti & Loreto Ge, 2014. "Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-15, June.

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