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High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers

Author

Listed:
  • Olivier Lambotte
  • Justin Pollara
  • Faroudy Boufassa
  • Christiane Moog
  • Alain Venet
  • Barton F Haynes
  • Jean-François Delfraissy
  • Asier Saez-Cirion
  • Guido Ferrari

Abstract

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.

Suggested Citation

  • Olivier Lambotte & Justin Pollara & Faroudy Boufassa & Christiane Moog & Alain Venet & Barton F Haynes & Jean-François Delfraissy & Asier Saez-Cirion & Guido Ferrari, 2013. "High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-5, September.
    • Handle: RePEc:plo:pone00:0074855
    DOI: 10.1371/journal.pone.0074855
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    References listed on IDEAS

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    1. Ann J. Hessell & Lars Hangartner & Meredith Hunter & Carin E. G. Havenith & Frank J. Beurskens & Joost M. Bakker & Caroline M. S. Lanigan & Gary Landucci & Donald N. Forthal & Paul W. H. I. Parren & P, 2007. "Fc receptor but not complement binding is important in antibody protection against HIV," Nature, Nature, vol. 449(7158), pages 101-104, September.
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    1. Luis M. Molinos-Albert & Valérie Lorin & Valérie Monceaux & Sylvie Orr & Asma Essat & Jérémy Dufloo & Olivier Schwartz & Christine Rouzioux & Laurence Meyer & Laurent Hocqueloux & Asier Sáez-Cirión & , 2022. "Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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