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Prognostic Value of Cancer Stem Cell Marker CD133 Expression in Gastric Cancer: A Systematic Review

Author

Listed:
  • Lei Wen
  • Xin-Zu Chen
  • Kun Yang
  • Zhi-Xin Chen
  • Bo Zhang
  • Jia-Ping Chen
  • Zong-Guang Zhou
  • Xian-Ming Mo
  • Jian-Kun Hu

Abstract

Objective: To investigate the correlation between CD133-positive gastric cancer and clinicopathological features and its impact on survival. Methods: A search in the Medline and Chinese CNKI (up to 1 Dec 2011) was performed using the following keywords gastric cancer, CD133, AC133, prominin-1 etc. Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings. Outcomes included overall survival and various clinicopathological features. Results: A total of 773 gastric cancer patients from 7 studies were included. The median rate of CD133 expression by immunohistochemistry (IHC) was 44.8% (15.2%–57.4%) from 5 studies, and that by reverse transcription polymerase chain reaction (RT-PCR) was 91.3% (66.7%–100%) from 4 studies. The accumulative 5-year overall survival rates of CD133-positive and CD133-negative patients were 21.4% and 55.7%, respectively. Meta-analysis showed that CD133-positive patients had a significant worse 5-year overall survival compared to the negative ones (OR = 0.20, 95% CI 0.14–0.29, P

Suggested Citation

  • Lei Wen & Xin-Zu Chen & Kun Yang & Zhi-Xin Chen & Bo Zhang & Jia-Ping Chen & Zong-Guang Zhou & Xian-Ming Mo & Jian-Kun Hu, 2013. "Prognostic Value of Cancer Stem Cell Marker CD133 Expression in Gastric Cancer: A Systematic Review," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-5, March.
    • Handle: RePEc:plo:pone00:0059154
    DOI: 10.1371/journal.pone.0059154
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    1. Catherine A. O’Brien & Aaron Pollett & Steven Gallinger & John E. Dick, 2007. "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice," Nature, Nature, vol. 445(7123), pages 106-110, January.
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