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Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis

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  • Zhuoxian Zhao
  • Sheyu Li
  • Guanjian Liu
  • Fangfang Yan
  • Xuelei Ma
  • Zeyu Huang
  • Haoming Tian

Abstract

Background and Objective: Emerging evidence from biological and epidemiological studies has suggested that body iron stores and heme-iron intake may be related to the risk of type 2 diabetes (T2D). We aimed to examine the association of body iron stores and heme-iron intake with T2D risk by conducting a systematic review and meta-analysis of previously published studies. Research Design and Methods: Systematic review and subsequent meta-analysis were conducted by searching MEDLINE database up to June 22, 2012 to identify studies that analyzed the association of body iron stores or dietary heme-iron intake with T2D risk. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculate the pooled risk estimates, while the heterogeneity among studies was examined using the I2 and Q statistic. Results: The meta-analysis included 16 high-quality studies: 12 studies analyzed ferritin levels (4,366 T2D patients and 41,091 controls) and 4 measured heme-iron intake (9,246 T2D patients and 179,689 controls). The combined relative risk (RR) comparing the highest and lowest category of ferritin levels was 1.66 (95% CI: 1.15–2.39) for prospective studies, 2.29 (95% CI: 1.48–3.54) for cross-sectional studies with heterogeneity (Q = 14.84, p = 0.01, I2 = 66.3%; Q = 44.16, p

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  • Zhuoxian Zhao & Sheyu Li & Guanjian Liu & Fangfang Yan & Xuelei Ma & Zeyu Huang & Haoming Tian, 2012. "Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-17, July.
    • Handle: RePEc:plo:pone00:0041641
    DOI: 10.1371/journal.pone.0041641
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    Cited by:

    1. Diana Bogueva & David Julian McClements, 2023. "Safety and Nutritional Risks Associated with Plant-Based Meat Alternatives," Sustainability, MDPI, vol. 15(19), pages 1-28, September.
    2. M Pilar Vaquero & Francisco J Sánchez Muniz, 2018. "Dysmetabolic Iron Overload and Cardiometabolic Diseases. Cause-Effect Relationship or Indirect Association?," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 8(1), pages 6-10, July.
    3. Shila Minari Hargreaves & António Raposo & Ariana Saraiva & Renata Puppin Zandonadi, 2021. "Vegetarian Diet: An Overview through the Perspective of Quality of Life Domains," IJERPH, MDPI, vol. 18(8), pages 1-23, April.

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