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Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo

Author

Listed:
  • Kun-Ju Zhu
  • Yong-Mei Lv
  • Xian-Yong Yin
  • Zai-Xing Wang
  • Liang-Dan Sun
  • Su-Min He
  • Hui Cheng
  • Da-Yan Hu
  • Zheng Zhang
  • Yang Li
  • Xian-Bo Zuo
  • You-Wen Zhou
  • Sen Yang
  • Xing Fan
  • Xue-Jun Zhang
  • Feng-Yu Zhang

Abstract

Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association. With four regression models obtained, two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 locus were associated with psoriasis. More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.

Suggested Citation

  • Kun-Ju Zhu & Yong-Mei Lv & Xian-Yong Yin & Zai-Xing Wang & Liang-Dan Sun & Su-Min He & Hui Cheng & Da-Yan Hu & Zheng Zhang & Yang Li & Xian-Bo Zuo & You-Wen Zhou & Sen Yang & Xing Fan & Xue-Jun Zhang , 2011. "Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0023089
    DOI: 10.1371/journal.pone.0023089
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    1. Lynn Petukhova & Madeleine Duvic & Maria Hordinsky & David Norris & Vera Price & Yutaka Shimomura & Hyunmi Kim & Pallavi Singh & Annette Lee & Wei V. Chen & Katja C. Meyer & Ralf Paus & Colin A. B. Ja, 2010. "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity," Nature, Nature, vol. 466(7302), pages 113-117, July.
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    1. Mathias Seviiri & Matthew H. Law & Jue-Sheng Ong & Puya Gharahkhani & Pierre Fontanillas & Catherine M. Olsen & David C. Whiteman & Stuart MacGregor, 2022. "A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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