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A Dynamic Model for Stem Cell Homeostasis and Patterning in Arabidopsis Meristems

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  • Tim Hohm
  • Eckart Zitzler
  • Rüdiger Simon

Abstract

Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalling between stem cells and surrounding cells. We have here simulated the origin and maintenance of a defined stem cell domain at the tip of Arabidopsis shoot meristems, based on the assumption that meristems are self-organizing systems. The model comprises two coupled feedback regulated genetic systems that control stem cell behaviour. Using a minimal set of spatial parameters, the mathematical model allows to predict the generation, shape and size of the stem cell domain, and the underlying organizing centre. We use the model to explore the parameter space that allows stem cell maintenance, and to simulate the consequences of mutations, gene misexpression and cell ablations.

Suggested Citation

  • Tim Hohm & Eckart Zitzler & Rüdiger Simon, 2010. "A Dynamic Model for Stem Cell Homeostasis and Patterning in Arabidopsis Meristems," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0009189
    DOI: 10.1371/journal.pone.0009189
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    References listed on IDEAS

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    1. Andrea Leibfried & Jennifer P. C. To & Wolfgang Busch & Sandra Stehling & Andreas Kehle & Monika Demar & Joseph J. Kieber & Jan U. Lohmann, 2005. "WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators," Nature, Nature, vol. 438(7071), pages 1172-1175, December.
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