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Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

Author

Listed:
  • Samuel E Jones
  • Jessica Tyrrell
  • Andrew R Wood
  • Robin N Beaumont
  • Katherine S Ruth
  • Marcus A Tuke
  • Hanieh Yaghootkar
  • Youna Hu
  • Maris Teder-Laving
  • Caroline Hayward
  • Till Roenneberg
  • James F Wilson
  • Fabiola Del Greco
  • Andrew A Hicks
  • Chol Shin
  • Chang-Ho Yun
  • Seung Ku Lee
  • Andres Metspalu
  • Enda M Byrne
  • Philip R Gehrman
  • Henning Tiemeier
  • Karla V Allebrandt
  • Rachel M Freathy
  • Anna Murray
  • David A Hinds
  • Timothy M Frayling
  • Michael N Weedon

Abstract

Disrupted circadian rhythms and reduced sleep duration are associated with several human diseases, particularly obesity and type 2 diabetes, but until recently, little was known about the genetic factors influencing these heritable traits. We performed genome-wide association studies of self-reported chronotype (morning/evening person) and self-reported sleep duration in 128,266 white British individuals from the UK Biobank study. Sixteen variants were associated with chronotype (P

Suggested Citation

  • Samuel E Jones & Jessica Tyrrell & Andrew R Wood & Robin N Beaumont & Katherine S Ruth & Marcus A Tuke & Hanieh Yaghootkar & Youna Hu & Maris Teder-Laving & Caroline Hayward & Till Roenneberg & James , 2016. "Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci," PLOS Genetics, Public Library of Science, vol. 12(8), pages 1-19, August.
    • Handle: RePEc:plo:pgen00:1006125
    DOI: 10.1371/journal.pgen.1006125
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    References listed on IDEAS

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    1. Biliana Marcheva & Kathryn Moynihan Ramsey & Ethan D. Buhr & Yumiko Kobayashi & Hong Su & Caroline H. Ko & Ganka Ivanova & Chiaki Omura & Shelley Mo & Martha H. Vitaterna & James P. Lopez & Louis H. P, 2010. "Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes," Nature, Nature, vol. 466(7306), pages 627-631, July.
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    Cited by:

    1. Huimin Li & Yong Zhang, 2022. "Effects of Physical Activity and Circadian Rhythm Differences on the Mental Health of College Students in Schools Closed by COVID-19," IJERPH, MDPI, vol. 20(1), pages 1-7, December.
    2. Victoria Garfield, 2019. "The Association Between Body Mass Index (BMI) and Sleep Duration: Where Are We after nearly Two Decades of Epidemiological Research?," IJERPH, MDPI, vol. 16(22), pages 1-12, November.

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