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A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

Author

Listed:
  • Rehan Qayyum
  • Beverly M Snively
  • Elad Ziv
  • Michael A Nalls
  • Yongmei Liu
  • Weihong Tang
  • Lisa R Yanek
  • Leslie Lange
  • Michele K Evans
  • Santhi Ganesh
  • Melissa A Austin
  • Guillaume Lettre
  • Diane M Becker
  • Alan B Zonderman
  • Andrew B Singleton
  • Tamara B Harris
  • Emile R Mohler
  • Benjamin A Logsdon
  • Charles Kooperberg
  • Aaron R Folsom
  • James G Wilson
  • Lewis C Becker
  • Alexander P Reiner

Abstract

Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV. For all cohorts, GWAS analysis was performed using additive models after adjusting for age, sex, and population stratification. For both platelet phenotypes, meta-analyses were conducted using inverse-variance weighted fixed-effect models. Platelet aggregation assays in whole blood were performed in the participants of the GeneSTAR cohort. Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p

Suggested Citation

  • Rehan Qayyum & Beverly M Snively & Elad Ziv & Michael A Nalls & Yongmei Liu & Weihong Tang & Lisa R Yanek & Leslie Lange & Michele K Evans & Santhi Ganesh & Melissa A Austin & Guillaume Lettre & Diane, 2012. "A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans," PLOS Genetics, Public Library of Science, vol. 8(3), pages 1-11, March.
    • Handle: RePEc:plo:pgen00:1002491
    DOI: 10.1371/journal.pgen.1002491
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    References listed on IDEAS

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    1. Silvia Tore & Stefania Casula & Giuseppina Casu & Maria Pina Concas & Paola Pistidda & Ivana Persico & Alessandro Sassu & Giovanni Battista Maestrale & Caterina Mele & Maria Rosa Caruso & Bibiana Bone, 2011. "Application of a New Method for GWAS in a Related Case/Control Sample with Known Pedigree Structure: Identification of New Loci for Nephrolithiasis," PLOS Genetics, Public Library of Science, vol. 7(1), pages 1-15, January.
    2. Melanie Kolz & Toby Johnson & Serena Sanna & Alexander Teumer & Veronique Vitart & Markus Perola & Massimo Mangino & Eva Albrecht & Chris Wallace & Martin Farrall & Åsa Johansson & Dale R Nyholt & Yur, 2009. "Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-10, June.
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    1. Rafał Rudzik & Violetta Dziedziejko & Monika Ewa Rać & Marek Sawczuk & Agnieszka Maciejewska-Skrendo & Krzysztof Safranow & Andrzej Pawlik, 2020. "Polymorphisms in GP6 , PEAR1A , MRVI1 , PIK3CG , JMJD1C , and SHH Genes in Patients with Unstable Angina," IJERPH, MDPI, vol. 17(20), pages 1-14, October.

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