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Polymorphisms in GP6 , PEAR1A , MRVI1 , PIK3CG , JMJD1C , and SHH Genes in Patients with Unstable Angina

Author

Listed:
  • Rafał Rudzik

    (Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Violetta Dziedziejko

    (Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Monika Ewa Rać

    (Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Marek Sawczuk

    (Insitute of Physical Culture Sciences, University of Szczecin, 70-111 Szczecin, Poland)

  • Agnieszka Maciejewska-Skrendo

    (Faculty of Physical Culture, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Krzysztof Safranow

    (Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Andrzej Pawlik

    (Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland)

Abstract

Introduction: Coronary artery disease (CAD) is a significant public health problem because it is one of the major causes of death worldwide. Several studies have investigated the associations between CAD and polymorphisms in genes connected with platelet aggregation and the risk of venous thromboembolism. Aim: In this study, we examined the associations between polymorphisms in GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and CAD in the form of unstable angina as well as selected clinical and biochemical parameters. The study enrolled 246 patients with diagnosed unstable angina and 189 healthy controls. Results: There were no significant differences in the distribution of the studied polymorphisms between the patients with unstable angina and the controls. In patients with the GP6 rs1671152 GG genotype, we observed increased BMI values and an increased frequency of type 2 diabetes diagnosis. Conclusions: The results of this study suggest a lack of association between GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and unstable angina. The results indicate an association between GP6 (rs1671152) and type 2 diabetes.

Suggested Citation

  • Rafał Rudzik & Violetta Dziedziejko & Monika Ewa Rać & Marek Sawczuk & Agnieszka Maciejewska-Skrendo & Krzysztof Safranow & Andrzej Pawlik, 2020. "Polymorphisms in GP6 , PEAR1A , MRVI1 , PIK3CG , JMJD1C , and SHH Genes in Patients with Unstable Angina," IJERPH, MDPI, vol. 17(20), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:20:p:7506-:d:428486
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    References listed on IDEAS

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    1. Christian Gieger & Aparna Radhakrishnan & Ana Cvejic & Weihong Tang & Eleonora Porcu & Giorgio Pistis & Jovana Serbanovic-Canic & Ulrich Elling & Alison H. Goodall & Yann Labrune & Lorna M. Lopez & Re, 2011. "New gene functions in megakaryopoiesis and platelet formation," Nature, Nature, vol. 480(7376), pages 201-208, December.
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    3. Seung Hoan Choi & Daniela Ruggiero & Rossella Sorice & Ci Song & Teresa Nutile & Albert Vernon Smith & Maria Pina Concas & Michela Traglia & Caterina Barbieri & Ndeye Coumba Ndiaye & Maria G Stathopou, 2016. "Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 12(2), pages 1-23, February.
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