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Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior

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  • Damian M Herz
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Miriam Auer
  • Muthuraman Muthuraman
  • Martin Glaser
  • Rafal Bogacz
  • Alek Pogosyan
  • Huiling Tan
  • Sergiu Groppa
  • Peter Brown

Abstract

Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome. However, the corresponding electrophysiological correlates in the basal ganglia and the extent to which these causally contribute to action adaptation in humans is unclear. Here, we recorded electrophysiological activity and applied bursts of electrical stimulation to the subthalamic nucleus, a core area of the basal ganglia, in 16 patients with Parkinson’s disease (PD) on medication using temporarily externalized deep brain stimulation (DBS) electrodes. Patients as well as 16 age- and gender-matched healthy participants attempted to produce forces as close as possible to a target force to collect a maximum number of points. The target force changed over trials without being explicitly shown on the screen so that participants had to infer target force based on the feedback they received after each movement. Patients and healthy participants were able to adapt their force according to the feedback they received (P

Suggested Citation

  • Damian M Herz & Manuel Bange & Gabriel Gonzalez-Escamilla & Miriam Auer & Muthuraman Muthuraman & Martin Glaser & Rafal Bogacz & Alek Pogosyan & Huiling Tan & Sergiu Groppa & Peter Brown, 2023. "Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior," PLOS Biology, Public Library of Science, vol. 21(6), pages 1-32, June.
    • Handle: RePEc:plo:pbio00:3002140
    DOI: 10.1371/journal.pbio.3002140
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    1. Damian M. Herz & Manuel Bange & Gabriel Gonzalez-Escamilla & Miriam Auer & Keyoumars Ashkan & Petra Fischer & Huiling Tan & Rafal Bogacz & Muthuraman Muthuraman & Sergiu Groppa & Peter Brown, 2022. "Dynamic control of decision and movement speed in the human basal ganglia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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