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Zonulin as a Biomarker in Mental Illness - Review

Author

Listed:
  • Miorita Melina Iordache

    („Ovidius†University of Constanta)

  • Cristina Tocia

    („Ovidius†University of Constanta)

Abstract

Mental health conditions are on the rise worldwide. This has determined an acceleration in the last two years in research focusing on mental health and brain-gut microbiome axis, highlighting the relevance of bidirectional communication. This systematic review aimed to gather evidence from studies of intestinal permeability biomarkers, in adults diagnosed with mental disorders, by following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The selected articles provided evidence of intestinal permeability in adults diagnosed with neurocognitive impairment in Alzheimer's disease, schizophrenia, depression and suicide risk, bipolar affective disorder and alcohol consumption. Research shows that increased permeability and changes in the intestinal microbiota contribute to the pathogenesis of mental disorders. These findings support that this intestinal permeability biomarker had a role in mental disorders, but more information is needed for shedding light on this topic.

Suggested Citation

  • Miorita Melina Iordache & Cristina Tocia, 2021. "Zonulin as a Biomarker in Mental Illness - Review," Ovidius University Annals, Economic Sciences Series, Ovidius University of Constantza, Faculty of Economic Sciences, vol. 0(2), pages 325-331, December.
    • Handle: RePEc:ovi:oviste:v:xxi:y:2021:i:2:p:325-331
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    More about this item

    Keywords

    biomarkers; mental disorders; Zonulin;
    All these keywords.

    JEL classification:

    • I13 - Health, Education, and Welfare - - Health - - - Health Insurance, Public and Private
    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

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