IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v571y2019i7763d10.1038_s41586-019-1352-7.html
   My bibliography  Save this article

Whole-animal connectomes of both Caenorhabditis elegans sexes

Author

Listed:
  • Steven J. Cook

    (Albert Einstein College of Medicine)

  • Travis A. Jarrell

    (Albert Einstein College of Medicine)

  • Christopher A. Brittin

    (Albert Einstein College of Medicine)

  • Yi Wang

    (Albert Einstein College of Medicine)

  • Adam E. Bloniarz

    (Google)

  • Maksim A. Yakovlev

    (Albert Einstein College of Medicine)

  • Ken C. Q. Nguyen

    (Albert Einstein College of Medicine)

  • Leo T.-H. Tang

    (Albert Einstein College of Medicine)

  • Emily A. Bayer

    (Columbia University)

  • Janet S. Duerr

    (Ohio University)

  • Hannes E. Bülow

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Oliver Hobert

    (Columbia University
    Columbia University)

  • David H. Hall

    (Albert Einstein College of Medicine)

  • Scott W. Emmons

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

Abstract

Knowledge of connectivity in the nervous system is essential to understanding its function. Here we describe connectomes for both adult sexes of the nematode Caenorhabditis elegans, an important model organism for neuroscience research. We present quantitative connectivity matrices that encompass all connections from sensory input to end-organ output across the entire animal, information that is necessary to model behaviour. Serial electron microscopy reconstructions that are based on the analysis of both new and previously published electron micrographs update previous results and include data on the male head. The nervous system differs between sexes at multiple levels. Several sex-shared neurons that function in circuits for sexual behaviour are sexually dimorphic in structure and connectivity. Inputs from sex-specific circuitry to central circuitry reveal points at which sexual and non-sexual pathways converge. In sex-shared central pathways, a substantial number of connections differ in strength between the sexes. Quantitative connectomes that include all connections serve as the basis for understanding how complex, adaptive behavior is generated.

Suggested Citation

  • Steven J. Cook & Travis A. Jarrell & Christopher A. Brittin & Yi Wang & Adam E. Bloniarz & Maksim A. Yakovlev & Ken C. Q. Nguyen & Leo T.-H. Tang & Emily A. Bayer & Janet S. Duerr & Hannes E. Bülow & , 2019. "Whole-animal connectomes of both Caenorhabditis elegans sexes," Nature, Nature, vol. 571(7763), pages 63-71, July.
    • Handle: RePEc:nat:nature:v:571:y:2019:i:7763:d:10.1038_s41586-019-1352-7
    DOI: 10.1038/s41586-019-1352-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-019-1352-7
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-019-1352-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yongbin Li & Siyu Chen & Weihong Liu & Di Zhao & Yimeng Gao & Shipeng Hu & Hanyu Liu & Yuanyuan Li & Lei Qu & Xiao Liu, 2024. "A full-body transcription factor expression atlas with completely resolved cell identities in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Robert Jankowski & Antoine Allard & Marián Boguñá & M. Ángeles Serrano, 2023. "The D-Mercator method for the multidimensional hyperbolic embedding of real networks," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Chenxi Lin & Yuxin Shan & Zhongyi Wang & Hui Peng & Rong Li & Pingzhou Wang & Junyan He & Weiwei Shen & Zhengxing Wu & Min Guo, 2024. "Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Hagar Setty & Yehuda Salzberg & Shadi Karimi & Elisheva Berent-Barzel & Michael Krieg & Meital Oren-Suissa, 2022. "Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Noa Deshe & Yifat Eliezer & Lihi Hoch & Eyal Itskovits & Eduard Bokman & Shachaf Ben-Ezra & Alon Zaslaver, 2023. "Inheritance of associative memories and acquired cellular changes in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Hyunsoo Yim & Daniel T. Choe & J. Alexander Bae & Myung-kyu Choi & Hae-Mook Kang & Ken C. Q. Nguyen & Soungyub Ahn & Sang-kyu Bahn & Heeseung Yang & David H. Hall & Jinseop S. Kim & Junho Lee, 2024. "Comparative connectomics of dauer reveals developmental plasticity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    7. Xu Zhan & Chao Chen & Longgang Niu & Xinran Du & Ying Lei & Rui Dan & Zhao-Wen Wang & Ping Liu, 2023. "Locomotion modulates olfactory learning through proprioception in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    8. Alexandra Segref & Kavya L. Vakkayil & Tsimafei Padvitski & Qiaochu Li & Virginia Kroef & Jakob Lormann & Lioba Körner & Fabian Finger & Thorsten Hoppe, 2022. "Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:571:y:2019:i:7763:d:10.1038_s41586-019-1352-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.