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Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Author

Listed:
  • Joana Carrelha

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Yiran Meng

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Laura M. Kettyle

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Tiago C. Luis

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Ruggiero Norfo

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Verónica Alcolea

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Hanane Boukarabila

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Cincinnati Children's Hospital Medical Center and University of Cincinnati)

  • Francesca Grasso

    (Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
    Karolinska University Hospital)

  • Adriana Gambardella

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Amit Grover

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Kari Högstrand

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Allegra M. Lord

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Alejandra Sanjuan-Pla

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Instituto de Investigación Sanitaria La Fe)

  • Petter S. Woll

    (Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
    Karolinska University Hospital)

  • Claus Nerlov

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Sten Eirik W. Jacobsen

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

Abstract

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

Suggested Citation

  • Joana Carrelha & Yiran Meng & Laura M. Kettyle & Tiago C. Luis & Ruggiero Norfo & Verónica Alcolea & Hanane Boukarabila & Francesca Grasso & Adriana Gambardella & Amit Grover & Kari Högstrand & Allegr, 2018. "Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells," Nature, Nature, vol. 554(7690), pages 106-111, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25455
    DOI: 10.1038/nature25455
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    Citations

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    Cited by:

    1. Yinghui Li & Mei He & Wenshan Zhang & Wei Liu & Hui Xu & Ming Yang & Hexiao Zhang & Haiwei Liang & Wenjing Li & Zhaozhao Wu & Weichao Fu & Shiqi Xu & Xiaolei Liu & Sibin Fan & Liwei Zhou & Chaoqun Wan, 2023. "Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Mina N. F. Morcos & Congxin Li & Clara M. Munz & Alessandro Greco & Nicole Dressel & Susanne Reinhardt & Katrin Sameith & Andreas Dahl & Nils B. Becker & Axel Roers & Thomas Höfer & Alexander Gerbaule, 2022. "Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Reuben Franklin & Yiming Guo & Shiyang He & Meijuan Chen & Fei Ji & Xinyue Zhou & David Frankhouser & Brian T. Do & Carmen Chiem & Mihyun Jang & M. Andres Blanco & Matthew G. Vander Heiden & Russell C, 2022. "Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Taichi Nakatani & Tatsuki Sugiyama & Yoshiki Omatsu & Hitomi Watanabe & Gen Kondoh & Takashi Nagasawa, 2023. "Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Tiago C. Luis & Nikolaos Barkas & Joana Carrelha & Alice Giustacchini & Stefania Mazzi & Ruggiero Norfo & Bishan Wu & Affaf Aliouat & Jose A. Guerrero & Alba Rodriguez-Meira & Tiphaine Bouriez-Jones &, 2023. "Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Brandon Hadland & Barbara Varnum-Finney & Stacey Dozono & Tessa Dignum & Cynthia Nourigat-McKay & Adam M. Heck & Takashi Ishida & Dana L. Jackson & Tomer Itkin & Jason M. Butler & Shahin Rafii & Cole , 2022. "Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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