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Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

Author

Listed:
  • Humsa S. Venkatesh

    (Stanford University School of Medicine
    Cancer Biology Graduate Program, Stanford University School of Medicine)

  • Lydia T. Tam

    (Stanford University School of Medicine)

  • Pamelyn J. Woo

    (Stanford University School of Medicine)

  • James Lennon

    (Stanford University School of Medicine)

  • Surya Nagaraja

    (Stanford University School of Medicine)

  • Shawn M. Gillespie

    (Stanford University School of Medicine
    Cancer Biology Graduate Program, Stanford University School of Medicine)

  • Jing Ni

    (Dana Farber Cancer Institute
    Harvard Medical School)

  • Damien Y. Duveau

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Patrick J. Morris

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Jean J. Zhao

    (Dana Farber Cancer Institute
    Harvard Medical School)

  • Craig J. Thomas

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Michelle Monje

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Stanford University School of Medicine
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

Abstract

The growth of adult and paediatric brain tumours depends on a microenvironmental signalling pathway involving the activity-regulated secretion of neuroligin-3 (NLGN3) from normal neurons and oligodendrocyte precursor cells, highlighting the potential of NLGN3 as a therapeutic target.

Suggested Citation

  • Humsa S. Venkatesh & Lydia T. Tam & Pamelyn J. Woo & James Lennon & Surya Nagaraja & Shawn M. Gillespie & Jing Ni & Damien Y. Duveau & Patrick J. Morris & Jean J. Zhao & Craig J. Thomas & Michelle Mon, 2017. "Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma," Nature, Nature, vol. 549(7673), pages 533-537, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7673:d:10.1038_nature24014
    DOI: 10.1038/nature24014
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    Cited by:

    1. Corina Anastasaki & Juan Mo & Ji-Kang Chen & Jit Chatterjee & Yuan Pan & Suzanne M. Scheaffer & Olivia Cobb & Michelle Monje & Lu Q. Le & David H. Gutmann, 2022. "Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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