IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v548y2017i7666d10.1038_nature23320.html
   My bibliography  Save this article

Proteins evolve on the edge of supramolecular self-assembly

Author

Listed:
  • Hector Garcia-Seisdedos

    (Weizmann Institute of Science)

  • Charly Empereur-Mot

    (Weizmann Institute of Science
    Conservatoire National des Arts et Métiers)

  • Nadav Elad

    (Weizmann Institute of Science)

  • Emmanuel D. Levy

    (Weizmann Institute of Science)

Abstract

Introducing a single ‘sticky’ (hydrophobic) amino acid by point mutation into symmetric protein complexes frequently triggers their association into higher-order assemblies, without affecting their native fold and structure.

Suggested Citation

  • Hector Garcia-Seisdedos & Charly Empereur-Mot & Nadav Elad & Emmanuel D. Levy, 2017. "Proteins evolve on the edge of supramolecular self-assembly," Nature, Nature, vol. 548(7666), pages 244-247, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7666:d:10.1038_nature23320
    DOI: 10.1038/nature23320
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23320
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature23320?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Christin Pohl & Gregory Effantin & Eaazhisai Kandiah & Sebastian Meier & Guanghong Zeng & Werner Streicher & Dorotea Raventos Segura & Per H. Mygind & Dorthe Sandvang & Line Anker Nielsen & Günther H., 2022. "pH- and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Lauren Ann Metskas & Davi Ortega & Luke M. Oltrogge & Cecilia Blikstad & Derik R. Lovejoy & Thomas G. Laughlin & David F. Savage & Grant J. Jensen, 2022. "Rubisco forms a lattice inside alpha-carboxysomes," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Johannes Venezian & Hagit Bar-Yosef & Hila Ben-Arie Zilberman & Noam Cohen & Oded Kleifeld & Juan Fernandez-Recio & Fabian Glaser & Ayala Shiber, 2024. "Diverging co-translational protein complex assembly pathways are governed by interface energy distribution," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Alexander S Leonard & Sebastian E Ahnert, 2019. "Evolution of interface binding strengths in simplified model of protein quaternary structure," PLOS Computational Biology, Public Library of Science, vol. 15(6), pages 1-15, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:548:y:2017:i:7666:d:10.1038_nature23320. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.