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Insights from biochemical reconstitution into the architecture of human kinetochores

Author

Listed:
  • John R. Weir

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Alex C. Faesen

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Kerstin Klare

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Arsen Petrovic

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Federica Basilico

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Josef Fischböck

    (Gene Center Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25)

  • Satyakrishna Pentakota

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Jenny Keller

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Marion E. Pesenti

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Dongqing Pan

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Doro Vogt

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Sabine Wohlgemuth

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11)

  • Franz Herzog

    (Gene Center Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25)

  • Andrea Musacchio

    (Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11
    Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitätsstraße)

Abstract

Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.

Suggested Citation

  • John R. Weir & Alex C. Faesen & Kerstin Klare & Arsen Petrovic & Federica Basilico & Josef Fischböck & Satyakrishna Pentakota & Jenny Keller & Marion E. Pesenti & Dongqing Pan & Doro Vogt & Sabine Woh, 2016. "Insights from biochemical reconstitution into the architecture of human kinetochores," Nature, Nature, vol. 537(7619), pages 249-253, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19333
    DOI: 10.1038/nature19333
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    Cited by:

    1. Yusuke Takenoshita & Masatoshi Hara & Tatsuo Fukagawa, 2022. "Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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